Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice.

Iracheta-Vellve, Arvin; Petrasek, Jan; Gyogyosi, Benedek; Bala, Shashi; Csak, Timea; Kodys, Karen; Szabo, Gyongyi

Iracheta-Vellve, Arvin; Petrasek, Jan; Gyogyosi, Benedek; Bala, Shashi; Csak, Timea; Kodys, Karen; Szabo, Gyongyi.

Affiliation

Iracheta-Vellve A; Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Petrasek J; Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Gyogyosi B; Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Bala S; Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Csak T; Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Kodys K; Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Szabo G; Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Liver Int ; 37(7): 968-973, 2017 07.

Article in En | MEDLINE | ID: mdl-28345165

Subject(s)

Acute-On-Chronic Liver Failure/drug therapy; Cell Proliferation/drug effects; Hepatitis, Alcoholic/drug therapy; Hepatocytes/drug effects; Interleukin 1 Receptor Antagonist Protein/pharmacology; Interleukin-1/antagonists & inhibitors; Liver Regeneration/drug effects; Liver/drug effects; Acute-On-Chronic Liver Failure/metabolism; Acute-On-Chronic Liver Failure/pathology; Acute-On-Chronic Liver Failure/physiopathology; Animals; Disease Models, Animal; Female; Hepatitis, Alcoholic/metabolism; Hepatitis, Alcoholic/pathology; Hepatitis, Alcoholic/physiopathology; Hepatocytes/metabolism; Hepatocytes/pathology; Interleukin-1/metabolism; Liver/metabolism; Liver/pathology; Liver/physiopathology; Mice, Inbred C57BL; Neutrophil Infiltration/drug effects; Recovery of Function; Signal Transduction/drug effects; Time Factors

Key words

alcoholic liver disease; interleukin 1; interleukin 1 receptor antagonist; liver regeneration

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Full text: 1 Database: MEDLINE Main subject: Interleukin-1 / Hepatocytes / Cell Proliferation / Interleukin 1 Receptor Antagonist Protein / Acute-On-Chronic Liver Failure / Hepatitis, Alcoholic / Liver / Liver Regeneration Type of study: Prognostic_studies Limits: Animals Language: En Journal: Liver Int Journal subject: GASTROENTEROLOGIA Year: 2017 Type: Article Affiliation country: United States

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