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Mitochondria-targeted antioxidant mitoquinone deactivates human and rat hepatic stellate cells and reduces portal hypertension in cirrhotic rats.
Vilaseca, Marina; García-Calderó, Héctor; Lafoz, Erica; Ruart, Maria; López-Sanjurjo, Cristina Isabel; Murphy, Michael P; Deulofeu, Ramon; Bosch, Jaume; Hernández-Gea, Virginia; Gracia-Sancho, Jordi; García-Pagán, Juan Carlos.
Affiliation
  • Vilaseca M; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.
  • García-Calderó H; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.
  • Lafoz E; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
  • Ruart M; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.
  • López-Sanjurjo CI; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.
  • Murphy MP; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.
  • Deulofeu R; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
  • Bosch J; MRC Mitochondrial Biology Unit, Cambridge, UK.
  • Hernández-Gea V; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
  • Gracia-Sancho J; Department of Biochemistry and Chromatography, Hospital Clinic de Barcelona, Barcelona, Spain.
  • García-Pagán JC; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.
Liver Int ; 37(7): 1002-1012, 2017 07.
Article in En | MEDLINE | ID: mdl-28371136
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Full text: 1 Database: MEDLINE Main subject: Organophosphorus Compounds / Mitochondria, Liver / Ubiquinone / Oxidative Stress / Hepatic Stellate Cells / Hypertension, Portal / Liver Cirrhosis, Experimental / Antioxidants Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Liver Int Journal subject: GASTROENTEROLOGIA Year: 2017 Type: Article Affiliation country: Spain
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Organophosphorus Compounds / Mitochondria, Liver / Ubiquinone / Oxidative Stress / Hepatic Stellate Cells / Hypertension, Portal / Liver Cirrhosis, Experimental / Antioxidants Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Liver Int Journal subject: GASTROENTEROLOGIA Year: 2017 Type: Article Affiliation country: Spain