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Of Mice and Men: Species-Specific Organoid Models of Neocortical Malformation.
Dunnack, Jesse J; LoTurco, Joseph J.
Affiliation
  • Dunnack JJ; Department of Physiology and Neurobiology, University of Connecticut Storrs, Storrs, CT 06269, USA.
  • LoTurco JJ; Department of Physiology and Neurobiology, University of Connecticut Storrs, Storrs, CT 06269, USA. Electronic address: joseph.loturco@uconn.edu.
Cell Stem Cell ; 20(4): 421-422, 2017 04 06.
Article in En | MEDLINE | ID: mdl-28388422
Cellular changes underlying malformations of human cortical development may be difficult to identify with traditional mouse models. Two recent Cell Stem Cell papers, Li et al. (2017) and Bershteyn et al. (2017), use human cerebral organoids to identify specific cellular defects in neurogenesis that may explain PTEN-related macrocephaly and Miller-Dieker lissencephaly.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Organoids / Neocortex Limits: Animals / Humans / Male Language: En Journal: Cell Stem Cell Year: 2017 Type: Article Affiliation country: United States

Full text: 1 Database: MEDLINE Main subject: Organoids / Neocortex Limits: Animals / Humans / Male Language: En Journal: Cell Stem Cell Year: 2017 Type: Article Affiliation country: United States