Of Mice and Men: Species-Specific Organoid Models of Neocortical Malformation.
Cell Stem Cell
; 20(4): 421-422, 2017 04 06.
Article
in En
| MEDLINE
| ID: mdl-28388422
Cellular changes underlying malformations of human cortical development may be difficult to identify with traditional mouse models. Two recent Cell Stem Cell papers, Li et al. (2017) and Bershteyn et al. (2017), use human cerebral organoids to identify specific cellular defects in neurogenesis that may explain PTEN-related macrocephaly and Miller-Dieker lissencephaly.
Full text:
1
Database:
MEDLINE
Main subject:
Organoids
/
Neocortex
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Cell Stem Cell
Year:
2017
Type:
Article
Affiliation country:
United States