Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities.
Curr Opin Genet Dev
; 42: 56-67, 2017 Feb.
Article
in En
| MEDLINE
| ID: mdl-28391084
ABSTRACT
Mammalian SWI/SNF (BAF) chromatin remodeling complexes orchestrate a diverse set of chromatin alterations which impact transcriptional output. Recent whole-exome sequencing efforts have revealed that the genes encoding subunits of mSWI/SNF complexes are mutated in over 20% of cancers, spanning a wide range of tissue types. The majority of mutations result in loss of subunit protein expression, implicating mSWI/SNF subunits as tumor suppressors. mSWI/SNF-deficient cancers remain a therapeutic challenge, owing to a lack of potent and selective agents which target complexes or unique pathway dependencies generated by mSWI/SNF subunit perturbations. Here, we review the current landscape of mechanistic insights and emerging therapeutic opportunities for human malignancies driven by mSWI/SNF complex perturbation.
Full text:
1
Database:
MEDLINE
Main subject:
Transcription Factors
/
Chromosomal Proteins, Non-Histone
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Genet Dev
Journal subject:
GENETICA
Year:
2017
Type:
Article
Affiliation country:
United States