Azithromycin Causes a Novel Proarrhythmic Syndrome.

Yang, Zhenjiang; Prinsen, Joseph K; Bersell, Kevin R; Shen, Wangzhen; Yermalitskaya, Liudmila; Sidorova, Tatiana; Luis, Paula B; Hall, Lynn; Zhang, Wei; Du, Liping; Milne, Ginger; Tucker, Patrick; George, Alfred L; Campbell, Courtney M; Pickett, Robert A; Shaffer, Christian M; Chopra, Nagesh; Yang, Tao; Knollmann, Bjorn C; Roden, Dan M; Murray, Katherine T

Yang, Zhenjiang; Prinsen, Joseph K; Bersell, Kevin R; Shen, Wangzhen; Yermalitskaya, Liudmila; Sidorova, Tatiana; Luis, Paula B; Hall, Lynn; Zhang, Wei; Du, Liping; Milne, Ginger; Tucker, Patrick; George, Alfred L; Campbell, Courtney M; Pickett, Robert A; Shaffer, Christian M; Chopra, Nagesh; Yang, Tao; Knollmann, Bjorn C; Roden, Dan M; Murray, Katherine T.

Affiliation

Yang Z; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Prinsen JK; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Bersell KR; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Shen W; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Yermalitskaya L; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Sidorova T; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Luis PB; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Hall L; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Zhang W; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Du L; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Milne G; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Tucker P; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
George AL; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Campbell CM; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Pickett RA; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Shaffer CM; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Chopra N; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Yang T; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Knollmann BC; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Roden DM; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Murray KT; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN. kathy.murray@vanderbilt.edu.

Circ Arrhythm Electrophysiol ; 10(4)2017 Apr.

Article in En | MEDLINE | ID: mdl-28408648

Subject(s)

Anti-Bacterial Agents/toxicity; Arrhythmias, Cardiac/chemically induced; Azithromycin/toxicity; Heart Rate/drug effects; Myocytes, Cardiac/drug effects; Action Potentials; Animals; Arrhythmias, Cardiac/metabolism; Arrhythmias, Cardiac/physiopathology; CHO Cells; Calcium Channel Blockers/toxicity; Calcium Channels, L-Type/drug effects; Calcium Channels, L-Type/genetics; Calcium Channels, L-Type/metabolism; Cricetulus; Dose-Response Relationship, Drug; Electrocardiography, Ambulatory; Female; HEK293 Cells; Humans; KCNQ1 Potassium Channel/antagonists & inhibitors; KCNQ1 Potassium Channel/genetics; KCNQ1 Potassium Channel/metabolism; Mice, Inbred C57BL; Myocytes, Cardiac/metabolism; NAV1.5 Voltage-Gated Sodium Channel/drug effects; NAV1.5 Voltage-Gated Sodium Channel/genetics; NAV1.5 Voltage-Gated Sodium Channel/metabolism; Potassium Channel Blockers/toxicity; Potassium Channels, Inwardly Rectifying/antagonists & inhibitors; Potassium Channels, Inwardly Rectifying/genetics; Potassium Channels, Inwardly Rectifying/metabolism; Potassium Channels, Voltage-Gated/antagonists & inhibitors; Potassium Channels, Voltage-Gated/genetics; Potassium Channels, Voltage-Gated/metabolism; Rabbits; Sodium Channel Blockers/toxicity; Telemetry; Time Factors; Transfection; Young Adult

Key words

calcium channel; mice; pharmacology; potassium channels; sodium channels

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Arrhythmias, Cardiac / Azithromycin / Myocytes, Cardiac / Heart Rate / Anti-Bacterial Agents Type of study: Etiology_studies Language: En Journal: Circ Arrhythm Electrophysiol Journal subject: ANGIOLOGIA / CARDIOLOGIA Year: 2017 Type: Article Affiliation country: Tunisia

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google