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Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.
Arce Vargas, Frederick; Furness, Andrew J S; Solomon, Isabelle; Joshi, Kroopa; Mekkaoui, Leila; Lesko, Marta H; Miranda Rota, Enrique; Dahan, Rony; Georgiou, Andrew; Sledzinska, Anna; Ben Aissa, Assma; Franz, Dafne; Werner Sunderland, Mariana; Wong, Yien Ning Sophia; Henry, Jake Y; O'Brien, Tim; Nicol, David; Challacombe, Ben; Beers, Stephen A; Turajlic, Samra; Gore, Martin; Larkin, James; Swanton, Charles; Chester, Kerry A; Pule, Martin; Ravetch, Jeffrey V; Marafioti, Teresa; Peggs, Karl S; Quezada, Sergio A.
Affiliation
  • Arce Vargas F; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Furness AJS; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK; The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.
  • Solomon I; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Joshi K; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK; The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.
  • Mekkaoui L; Research Department of Oncology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Lesko MH; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Miranda Rota E; Research Department of Oncology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Dahan R; Leonard Wagner Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Georgiou A; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Sledzinska A; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Ben Aissa A; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Franz D; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Werner Sunderland M; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Wong YNS; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Henry JY; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.
  • O'Brien T; Guy's and St. Thomas' NHS Foundation Trust, London SE1 9RT, UK.
  • Nicol D; The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.
  • Challacombe B; Guy's and St. Thomas' NHS Foundation Trust, London SE1 9RT, UK.
  • Beers SA; Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton, Faculty of Medicine, Southampton SO17 1BJ, UK.
  • Turajlic S; The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK; The Francis Crick Institute, London NW1 1AT, UK.
  • Gore M; The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.
  • Larkin J; The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.
  • Swanton C; The Francis Crick Institute, London NW1 1AT, UK; Translational Cancer Therapeutics Laboratory, UCL Cancer Institute, London WC1E 6DD, UK.
  • Chester KA; Research Department of Oncology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Pule M; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.
  • Ravetch JV; Leonard Wagner Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Marafioti T; Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK.
  • Peggs KS; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK. Electronic address: k.peggs@ucl.ac.uk.
  • Quezada SA; Cancer Immunology Unit, University College London Cancer Institute, London WC1E 6DD, UK; Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK. Electronic address: s.quezada@ucl.ac.uk.
Immunity ; 46(4): 577-586, 2017 04 18.
Article in En | MEDLINE | ID: mdl-28410988
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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin Fc Fragments / T-Lymphocytes, Regulatory / Interleukin-2 Receptor alpha Subunit / Programmed Cell Death 1 Receptor / Antibodies, Monoclonal / Neoplasms Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2017 Type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin Fc Fragments / T-Lymphocytes, Regulatory / Interleukin-2 Receptor alpha Subunit / Programmed Cell Death 1 Receptor / Antibodies, Monoclonal / Neoplasms Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2017 Type: Article Affiliation country: United kingdom