The X chromosome in space.
Nat Rev Genet
; 18(6): 377-389, 2017 06.
Article
in En
| MEDLINE
| ID: mdl-28479596
ABSTRACT
Extensive 3D folding is required to package a genome into the tiny nuclear space, and this packaging must be compatible with proper gene expression. Thus, in the well-hierarchized nucleus, chromosomes occupy discrete territories and adopt specific 3D organizational structures that facilitate interactions between regulatory elements for gene expression. The mammalian X chromosome exemplifies this structure-function relationship. Recent studies have shown that, upon X-chromosome inactivation, active and inactive X chromosomes localize to different subnuclear positions and adopt distinct chromosomal architectures that reflect their activity states. Here, we review the roles of long non-coding RNAs, chromosomal organizational structures and the subnuclear localization of chromosomes as they relate to X-linked gene expression.
Full text:
1
Database:
MEDLINE
Main subject:
X Chromosome
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Rev Genet
Journal subject:
GENETICA
Year:
2017
Type:
Article
Affiliation country:
United States