Prospective, randomized, double-blind, Phase 2 dose-ranging study comparing efficacy and safety of imipenem/cilastatin plus relebactam with imipenem/cilastatin alone in patients with complicated urinary tract infections.

Sims, Matthew; Mariyanovski, Valeri; McLeroth, Patrick; Akers, Wayne; Lee, Yu-Chieh; Brown, Michelle L; Du, Jiejun; Pedley, Alison; Kartsonis, Nicholas A; Paschke, Amanda

Sims, Matthew; Mariyanovski, Valeri; McLeroth, Patrick; Akers, Wayne; Lee, Yu-Chieh; Brown, Michelle L; Du, Jiejun; Pedley, Alison; Kartsonis, Nicholas A; Paschke, Amanda.

Affiliation

Sims M; William Beaumont Hospital, 3555 W. Thirteen Mile Road, Royal Oak, MI 48073, USA.
Mariyanovski V; University Hospital N. I. Pirogov, Boulevard Totleben 21, Sofia, Bulgaria.
McLeroth P; Covance Inc, 210 Carnegie Center, Princeton, NJ 08540, USA.
Akers W; Covance Inc, 210 Carnegie Center, Princeton, NJ 08540, USA.
Lee YC; Covance Inc, 210 Carnegie Center, Princeton, NJ 08540, USA.
Brown ML; Merck & Co., Inc, 2000 Galloping Hill Road, Kenilworth, NJ, USA.
Du J; Merck & Co., Inc, 2000 Galloping Hill Road, Kenilworth, NJ, USA.
Pedley A; Merck & Co., Inc, 2000 Galloping Hill Road, Kenilworth, NJ, USA.
Kartsonis NA; Merck & Co., Inc, 2000 Galloping Hill Road, Kenilworth, NJ, USA.
Paschke A; Merck & Co., Inc, 2000 Galloping Hill Road, Kenilworth, NJ, USA.

J Antimicrob Chemother ; 72(9): 2616-2626, 2017 09 01.

Article in En | MEDLINE | ID: mdl-28575389

Subject(s)

Anti-Bacterial Agents/adverse effects; Anti-Bacterial Agents/therapeutic use; Azabicyclo Compounds/therapeutic use; Cilastatin/therapeutic use; Imipenem/therapeutic use; Urinary Tract Infections/drug therapy; Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents/administration & dosage; Azabicyclo Compounds/administration & dosage; Azabicyclo Compounds/adverse effects; Cilastatin/administration & dosage; Cilastatin/adverse effects; Cilastatin, Imipenem Drug Combination; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Gram-Negative Bacterial Infections/drug therapy; Gram-Negative Bacterial Infections/microbiology; Humans; Imipenem/administration & dosage; Imipenem/adverse effects; Male; Middle Aged; Prospective Studies; Pyelonephritis/drug therapy; Urinary Tract Infections/microbiology; Young Adult; beta-Lactamase Inhibitors/administration & dosage; beta-Lactamase Inhibitors/adverse effects; beta-Lactamase Inhibitors/therapeutic use

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Full text: 1 Database: MEDLINE Main subject: Urinary Tract Infections / Cilastatin / Imipenem / Azabicyclo Compounds / Anti-Bacterial Agents Type of study: Clinical_trials / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Antimicrob Chemother Year: 2017 Type: Article Affiliation country: United States

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