Association of a reactive intermediate derived from 1',6-dihydroxy metabolite with benzbromarone-induced hepatotoxicity.

Yoshida, Mina; Cho, Naoki; Akita, Hidetaka; Kobayashi, Kaoru

Yoshida, Mina; Cho, Naoki; Akita, Hidetaka; Kobayashi, Kaoru.

Affiliation

Yoshida M; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Cho N; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Akita H; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Kobayashi K; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

J Biochem Mol Toxicol ; 31(10)2017 Oct.

Article in En | MEDLINE | ID: mdl-28598529

Subject(s)

Benzbromarone/pharmacokinetics; Benzbromarone/toxicity; Chemical and Drug Induced Liver Injury/metabolism; Liver/metabolism; Microsomes, Liver/metabolism; Animals; Chemical and Drug Induced Liver Injury/pathology; Liver/pathology; Male; Mice; Mice, Inbred ICR; Microsomes, Liver/pathology

Key words

Benzbromarone; hepatotoxicity; liver injury; reactive intermediate

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Full text: 1 Database: MEDLINE Main subject: Benzbromarone / Microsomes, Liver / Chemical and Drug Induced Liver Injury / Liver Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Biochem Mol Toxicol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Year: 2017 Type: Article Affiliation country: Japan

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