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Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.
Collier, Timothy J; Srivastava, Kinshuk R; Justman, Craig; Grammatopoulous, Tom; Hutter-Paier, Birgit; Prokesch, Manuela; Havas, Daniel; Rochet, Jean-Christophe; Liu, Fang; Jock, Kevin; de Oliveira, Patrícia; Stirtz, Georgia L; Dettmer, Ulf; Sortwell, Caryl E; Feany, Mel B; Lansbury, Peter; Lapidus, Lisa; Paumier, Katrina L.
Affiliation
  • Collier TJ; Department of Translational Science and Molecular Medicine, Michigan State University, Grand Rapids, MI, USA; Mercy Health Hauenstein Neuroscience Center, Grand Rapids, MI, USA. Electronic address: timothy.collier@hc.msu.edu.
  • Srivastava KR; Department of Physics and Astronomy, Michigan State University, East Lansing, MI, USA.
  • Justman C; Lysosomal Therapeutics, Inc., Cambridge, MA, USA.
  • Grammatopoulous T; BioEnergetics, Boston, MA, USA.
  • Hutter-Paier B; QPS Research, Graz, Austria.
  • Prokesch M; QPS Research, Graz, Austria.
  • Havas D; QPS Research, Graz, Austria.
  • Rochet JC; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
  • Liu F; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
  • Jock K; Department of Physics and Astronomy, Michigan State University, East Lansing, MI, USA.
  • de Oliveira P; Department of Physics and Astronomy, Michigan State University, East Lansing, MI, USA.
  • Stirtz GL; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Dettmer U; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Sortwell CE; Department of Translational Science and Molecular Medicine, Michigan State University, Grand Rapids, MI, USA; Mercy Health Hauenstein Neuroscience Center, Grand Rapids, MI, USA.
  • Feany MB; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
  • Lansbury P; Lysosomal Therapeutics, Inc., Cambridge, MA, USA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Lapidus L; Department of Physics and Astronomy, Michigan State University, East Lansing, MI, USA.
  • Paumier KL; Department of Neurology, Washington University, Saint Louis, MO, USA.
Neurobiol Dis ; 106: 191-204, 2017 Oct.
Article in En | MEDLINE | ID: mdl-28711409
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Full text: 1 Database: MEDLINE Main subject: Neuroprotective Agents / Neurodegenerative Diseases / Alpha-Synuclein / Protein Aggregation, Pathological / Neurons / Nortriptyline Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2017 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Neuroprotective Agents / Neurodegenerative Diseases / Alpha-Synuclein / Protein Aggregation, Pathological / Neurons / Nortriptyline Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2017 Type: Article