The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis.

Bush, Kevin T; Wu, Wei; Lun, Christina; Nigam, Sanjay K

Bush, Kevin T; Wu, Wei; Lun, Christina; Nigam, Sanjay K.

Affiliation

Bush KT; From the Departments of Pediatrics.
Wu W; Medicine, and.
Lun C; Biology, University of California San Diego, La Jolla, California 92093.
Nigam SK; From the Departments of Pediatrics, snigam@ucsd.edu.

J Biol Chem ; 292(38): 15789-15803, 2017 09 22.

Article in En | MEDLINE | ID: mdl-28765282

Subject(s)

Intestinal Mucosa/metabolism; Kidney/metabolism; Liver/metabolism; Organic Anion Transporters, Sodium-Independent/metabolism; Amino Acids/metabolism; Animals; Bile Acids and Salts/metabolism; Diet; Energy Metabolism; Gastrointestinal Microbiome; Gene Knockout Techniques; Intestines/microbiology; Ligands; Lipid Metabolism; Male; Metabolomics; Mice; Mice, Inbred C57BL; Organic Anion Transport Protein 1/metabolism; Organic Anion Transporters, Sodium-Independent/deficiency; Organic Anion Transporters, Sodium-Independent/genetics; Substrate Specificity; Xenobiotics/metabolism

Key words

OAT3; drug transport; kidney; kidney drug transport; multidrug transporter; organic anion; renal physiology; solute carrier; uremic toxin; xenobiotic

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Full text: 1 Database: MEDLINE Main subject: Organic Anion Transporters, Sodium-Independent / Intestinal Mucosa / Kidney / Liver Limits: Animals Language: En Journal: J Biol Chem Year: 2017 Type: Article

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