Parental preferences toward genomic sequencing for non-medically actionable conditions in children: a discrete-choice experiment.
Genet Med
; 20(2): 181-189, 2018 02.
Article
in En
| MEDLINE
| ID: mdl-28771249
ABSTRACT
PurposeApplication of whole-exome and whole-genome sequencing is likely to increase in clinical practice, public health contexts, and research. We investigated how parental preference for acquiring information from genome-scale testing is influenced by the characteristics of non-medically actionable genetic disorders in children, as well as whether the preferences differed by gender and between African-American and white respondents.MethodsWe conducted a Web-based discrete-choice experiment with 1,289 parents of young children. Participants completed "choice tasks" based on pairs of profiles describing sequencing results for hypothetical genetic disorders, selected the profile in each pair that they believed represented the information that would be more important to know, and answered questions that measured their level of distress.ResultsKnowing the likelihood that the disorder would develop given a true-positive test result was most important to parents. Parents showed greater interest in learning sequencing results for disease profiles with more severe manifestations. This was associated with greater distress. Differences by gender and race reflected small differences in magnitude, but not direction.ConclusionParents preferred to learn results about genetic disorders with more severe manifestations, even when this knowledge was associated with increased distress. These results may help clinicians support parental decision making by revealing which types of sequencing results parents are interested in learning.
Full text:
1
Database:
MEDLINE
Main subject:
Parents
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Choice Behavior
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Genetic Testing
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Decision Making
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Whole Genome Sequencing
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Genetic Diseases, Inborn
Type of study:
Prognostic_studies
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Qualitative_research
Limits:
Adult
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Child
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Female
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Humans
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Male
Language:
En
Journal:
Genet Med
Journal subject:
GENETICA MEDICA
Year:
2018
Type:
Article
Affiliation country:
United States