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Correction of a pathogenic gene mutation in human embryos.
Ma, Hong; Marti-Gutierrez, Nuria; Park, Sang-Wook; Wu, Jun; Lee, Yeonmi; Suzuki, Keiichiro; Koski, Amy; Ji, Dongmei; Hayama, Tomonari; Ahmed, Riffat; Darby, Hayley; Van Dyken, Crystal; Li, Ying; Kang, Eunju; Park, A-Reum; Kim, Daesik; Kim, Sang-Tae; Gong, Jianhui; Gu, Ying; Xu, Xun; Battaglia, David; Krieg, Sacha A; Lee, David M; Wu, Diana H; Wolf, Don P; Heitner, Stephen B; Belmonte, Juan Carlos Izpisua; Amato, Paula; Kim, Jin-Soo; Kaul, Sanjiv; Mitalipov, Shoukhrat.
Affiliation
  • Ma H; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Marti-Gutierrez N; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Park SW; Center for Genome Engineering, Institute for Basic Science, 70, Yuseong-daero 1689-gil, Yuseong-gu, Daejeon, 34047, Republic of Korea.
  • Wu J; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
  • Lee Y; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Suzuki K; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
  • Koski A; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Ji D; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Hayama T; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Ahmed R; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Darby H; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Van Dyken C; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Li Y; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Kang E; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Park AR; Center for Genome Engineering, Institute for Basic Science, 70, Yuseong-daero 1689-gil, Yuseong-gu, Daejeon, 34047, Republic of Korea.
  • Kim D; Department of Chemistry, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul, 151-747, Republic of Korea.
  • Kim ST; Center for Genome Engineering, Institute for Basic Science, 70, Yuseong-daero 1689-gil, Yuseong-gu, Daejeon, 34047, Republic of Korea.
  • Gong J; BGI-Shenzhen, Build 11, Beishan Industrial Zone, Yantian District, Shenzhen, 518083, China.
  • Gu Y; China National GeneBank, BGI-Shenzhen, Jinsha Road, Dapeng District, Shenzhen, 518210, China.
  • Xu X; BGI-Qingdao, 2877 Tuanjie Road, Sino-German Ecopark, Qingdao, 266000, China.
  • Battaglia D; Shenzhen Engineering Laboratory for Innovative Molecular Diagnostics, BGI-Shenzhen, Build 11, Beishan Industrial Zone, Yantian District, Shenzhen, 518083, China.
  • Krieg SA; BGI-Shenzhen, Build 11, Beishan Industrial Zone, Yantian District, Shenzhen, 518083, China.
  • Lee DM; China National GeneBank, BGI-Shenzhen, Jinsha Road, Dapeng District, Shenzhen, 518210, China.
  • Wu DH; BGI-Qingdao, 2877 Tuanjie Road, Sino-German Ecopark, Qingdao, 266000, China.
  • Wolf DP; BGI-Shenzhen, Build 11, Beishan Industrial Zone, Yantian District, Shenzhen, 518083, China.
  • Heitner SB; China National GeneBank, BGI-Shenzhen, Jinsha Road, Dapeng District, Shenzhen, 518210, China.
  • Belmonte JCI; BGI-Qingdao, 2877 Tuanjie Road, Sino-German Ecopark, Qingdao, 266000, China.
  • Amato P; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Kim JS; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Kaul S; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
  • Mitalipov S; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health &Science University, 3303 Southwest, Bond Avenue, Portland, Oregon 97239, USA.
Nature ; 548(7668): 413-419, 2017 08 24.
Article in En | MEDLINE | ID: mdl-28783728
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Full text: 1 Database: MEDLINE Main subject: Carrier Proteins / Embryo, Mammalian / Gene Editing / Mutation Limits: Adult / Humans / Male Language: En Journal: Nature Year: 2017 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Carrier Proteins / Embryo, Mammalian / Gene Editing / Mutation Limits: Adult / Humans / Male Language: En Journal: Nature Year: 2017 Type: Article Affiliation country: United States