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N-Acylated Derivatives of Sulfamethoxazole Block Chlamydia Fatty Acid Synthesis and Interact with FabF.
Mojica, Sergio A; Salin, Olli; Bastidas, Robert J; Sunduru, Naresh; Hedenström, Mattias; Andersson, C David; Núñez-Otero, Carlos; Engström, Patrik; Valdivia, Raphael H; Elofsson, Mikael; Gylfe, Åsa.
Affiliation
  • Mojica SA; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
  • Salin O; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
  • Bastidas RJ; Department of Molecular Genetics and Microbiology and Center for the Genomics of Microbial Systems, Duke University Medical Center, Durham, North Carolina, USA.
  • Sunduru N; Department of Chemistry, Umeå University, Umeå, Sweden.
  • Hedenström M; Department of Chemistry, Umeå University, Umeå, Sweden.
  • Andersson CD; Department of Chemistry, Umeå University, Umeå, Sweden.
  • Núñez-Otero C; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
  • Engström P; Department of Molecular Biology, Umeå University, Umeå, Sweden.
  • Valdivia RH; Department of Molecular Genetics and Microbiology and Center for the Genomics of Microbial Systems, Duke University Medical Center, Durham, North Carolina, USA.
  • Elofsson M; Department of Chemistry, Umeå University, Umeå, Sweden.
  • Gylfe Å; Molecular Infection Medicine Sweden, Umeå University, Umeå, Sweden.
Article in En | MEDLINE | ID: mdl-28784680

Full text: 1 Database: MEDLINE Main subject: Sulfamethoxazole / Chlamydia trachomatis / Fatty Acid Synthase, Type II / Fatty Acid Synthesis Inhibitors / Fatty Acids / Anti-Bacterial Agents Limits: Animals / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2017 Type: Article Affiliation country: Sweden

Full text: 1 Database: MEDLINE Main subject: Sulfamethoxazole / Chlamydia trachomatis / Fatty Acid Synthase, Type II / Fatty Acid Synthesis Inhibitors / Fatty Acids / Anti-Bacterial Agents Limits: Animals / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2017 Type: Article Affiliation country: Sweden