Adaptor Proteins, Signal Transducing/metabolism; Cell-Derived Microparticles/metabolism; Endosomal Sorting Complexes Required for Transport/metabolism; Myocytes, Cardiac/metabolism; Nerve Tissue Proteins/metabolism; Nuclear Proteins/metabolism; Tumor Suppressor Proteins/metabolism; Adaptor Proteins, Signal Transducing/blood; Adaptor Proteins, Signal Transducing/chemistry; Adaptor Proteins, Signal Transducing/genetics; Animals; Cell-Derived Microparticles/chemistry; Cell-Derived Microparticles/ultrastructure; Cells, Cultured; Endosomal Sorting Complexes Required for Transport/antagonists & inhibitors; Endosomal Sorting Complexes Required for Transport/blood; Endosomal Sorting Complexes Required for Transport/chemistry; Endosomal Sorting Complexes Required for Transport/genetics; Endosomal Sorting Complexes Required for Transport/ultrastructure; Enzyme-Linked Immunosorbent Assay; Exons; HeLa Cells; Heart Failure/blood; Heart Failure/pathology; Heterozygote; Humans; Mice, Transgenic; Microscopy, Electron, Transmission; Myocytes, Cardiac/cytology; Myocytes, Cardiac/pathology; Myocytes, Cardiac/ultrastructure; Nerve Tissue Proteins/blood; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/genetics; Nuclear Proteins/blood; Nuclear Proteins/chemistry; Nuclear Proteins/genetics; Particle Size; Peptide Fragments/blood; Peptide Fragments/chemistry; Peptide Fragments/metabolism; Protein Interaction Domains and Motifs; Protein Transport; RNA Interference; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Tumor Suppressor Proteins/blood; Tumor Suppressor Proteins/chemistry; Tumor Suppressor Proteins/genetics