Activation of Nuclear Factor-&#954;B by Tumor Necrosis Factor in Intestinal Epithelial Cells and Mouse Intestinal Epithelia Reduces Expression of the Chloride Transporter SLC26A3.

Kumar, Anoop; Chatterjee, Ishita; Gujral, Tarunmeet; Alakkam, Anas; Coffing, Hayley; Anbazhagan, Arivarasu N; Borthakur, Alip; Saksena, Seema; Gill, Ravinder K; Alrefai, Waddah A; Dudeja, Pradeep K

Activation of Nuclear Factor-κB by Tumor Necrosis Factor in Intestinal Epithelial Cells and Mouse Intestinal Epithelia Reduces Expression of the Chloride Transporter SLC26A3.

Kumar, Anoop; Chatterjee, Ishita; Gujral, Tarunmeet; Alakkam, Anas; Coffing, Hayley; Anbazhagan, Arivarasu N; Borthakur, Alip; Saksena, Seema; Gill, Ravinder K; Alrefai, Waddah A; Dudeja, Pradeep K.

Affiliation

Kumar A; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Chatterjee I; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Gujral T; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Alakkam A; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Coffing H; Department of Microbiology and Immunology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Anbazhagan AN; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Borthakur A; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Saksena S; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois.
Gill RK; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Alrefai WA; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois.
Dudeja PK; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Electronic address: pkdudeja@uic.edu.

Gastroenterology ; 153(5): 1338-1350.e3, 2017 11.

Article in En | MEDLINE | ID: mdl-28823863

Subject(s)

Antiporters/metabolism; Chloride-Bicarbonate Antiporters/metabolism; Diarrhea/etiology; Epithelial Cells/drug effects; Inflammatory Bowel Diseases/complications; Intestinal Mucosa/drug effects; NF-kappa B/metabolism; Tumor Necrosis Factor-alpha/pharmacology; Animals; Antiporters/genetics; Caco-2 Cells; Chloride-Bicarbonate Antiporters/genetics; Diarrhea/genetics; Diarrhea/metabolism; Dose-Response Relationship, Drug; Down-Regulation; Epithelial Cells/metabolism; Epithelial Cells/pathology; HT29 Cells; Humans; Inflammatory Bowel Diseases/genetics; Inflammatory Bowel Diseases/metabolism; Intestinal Absorption/drug effects; Intestinal Mucosa/metabolism; Intestinal Mucosa/pathology; Mice; Mice, Inbred C57BL; NF-kappa B/genetics; Promoter Regions, Genetic; RNA Interference; Sulfate Transporters; Time Factors; Transfection

Key words

Intestinal Inflammation; Ion Transporter; Mouse Model; NaCl Absorption

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Full text: 1 Database: MEDLINE Main subject: Inflammatory Bowel Diseases / NF-kappa B / Tumor Necrosis Factor-alpha / Antiporters / Chloride-Bicarbonate Antiporters / Diarrhea / Epithelial Cells / Intestinal Mucosa Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Gastroenterology Year: 2017 Type: Article

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