The binding of activated G&#945;<sub>q</sub> to phospholipase C-ß exhibits anomalous affinity.

Navaratnarajah, Punya; Gershenson, Anne; Ross, Elliott M

The binding of activated Gα_q to phospholipase C-ß exhibits anomalous affinity.

Navaratnarajah, Punya; Gershenson, Anne; Ross, Elliott M.

Affiliation

Navaratnarajah P; From the Department of Pharmacology and Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041 and.
Gershenson A; the Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 01003-9292.
Ross EM; From the Department of Pharmacology and Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041 and Elliott.Ross@UTSouthwestern.edu.

J Biol Chem ; 292(40): 16787-16801, 2017 10 06.

Article in En | MEDLINE | ID: mdl-28842497

Subject(s)

GTP-Binding Protein alpha Subunits, Gq-G11/chemistry; Models, Chemical; Phospholipase C beta/chemistry; Allosteric Regulation/physiology; Calcium/chemistry; Calcium/metabolism; Enzyme Activation; Fluorescence Resonance Energy Transfer; GTP-Binding Protein alpha Subunits, Gq-G11/genetics; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism; Humans; Isoenzymes/chemistry; Isoenzymes/genetics; Isoenzymes/metabolism; Kinetics; Phospholipase C beta/genetics; Phospholipase C beta/metabolism; Protein Binding

Key words

enzyme kinetics; fluorescence correlation spectroscopy (FCS); fluorescence resonance energy transfer (FRET); heterotrimeric G protein; phosphatidylinositol signaling; phospholipase C

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Full text: 1 Database: MEDLINE Main subject: GTP-Binding Protein alpha Subunits, Gq-G11 / Phospholipase C beta / Models, Chemical Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2017 Type: Article

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