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Solid-State Stability Issues of Drugs in Transdermal Patch Formulations.
Sharma, Purnendu Kumar; Panda, Apoorva; Pradhan, Adwait; Zhang, Jiaxiang; Thakkar, Ruchi; Whang, Chang-Hee; Repka, Michael A; Murthy, S Narasimha.
Affiliation
  • Sharma PK; Department of Pharmaceutics and Drug Delivery, The University of Mississippi, 113 Faser Hall, University, Mississippi, 38677, USA.
  • Panda A; Department of Pharmaceutics and Drug Delivery, The University of Mississippi, 113 Faser Hall, University, Mississippi, 38677, USA.
  • Pradhan A; Department of Pharmaceutics and Drug Delivery, The University of Mississippi, 113 Faser Hall, University, Mississippi, 38677, USA.
  • Zhang J; Department of Pharmaceutics and Drug Delivery, The University of Mississippi, 113 Faser Hall, University, Mississippi, 38677, USA.
  • Thakkar R; Department of Pharmaceutics and Drug Delivery, The University of Mississippi, 113 Faser Hall, University, Mississippi, 38677, USA.
  • Whang CH; Department of Pharmaceutics and Drug Delivery, The University of Mississippi, 113 Faser Hall, University, Mississippi, 38677, USA.
  • Repka MA; Department of Pharmaceutics and Drug Delivery, The University of Mississippi, 113 Faser Hall, University, Mississippi, 38677, USA.
  • Murthy SN; Department of Pharmaceutics and Drug Delivery, The University of Mississippi, 113 Faser Hall, University, Mississippi, 38677, USA. murthy@olemiss.edu.
AAPS PharmSciTech ; 19(1): 27-35, 2018 Jan.
Article in En | MEDLINE | ID: mdl-28895101
ABSTRACT
The transdermal patch formulation has many advantages, including noninvasiveness, an ability to bypass the first-pass metabolism, low dosage requirements, and prolonged drug delivery. However, the instability of solid-state drugs is one of the most critical problems observed in transdermal patch products. Therefore, a well-characterized approach for counteracting stability problems in solid-state drugs is crucial for improving the performance of transdermal patch products. This review provides insight into the solid-state stability of drugs associated with transdermal patch products and offers a comprehensive update on the various approaches being used for improving the stability of the active pharmaceutical ingredients currently being used.
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Full text: 1 Database: MEDLINE Main subject: Transdermal Patch Limits: Humans Language: En Journal: AAPS PharmSciTech Journal subject: FARMACOLOGIA Year: 2018 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Transdermal Patch Limits: Humans Language: En Journal: AAPS PharmSciTech Journal subject: FARMACOLOGIA Year: 2018 Type: Article Affiliation country: United States