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Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.
Dettmer, Ulf; Ramalingam, Nagendran; von Saucken, Victoria E; Kim, Tae-Eun; Newman, Andrew J; Terry-Kantor, Elizabeth; Nuber, Silke; Ericsson, Maria; Fanning, Saranna; Bartels, Tim; Lindquist, Susan; Levy, Oren A; Selkoe, Dennis.
Affiliation
  • Dettmer U; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Ramalingam N; Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
  • von Saucken VE; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Kim TE; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Newman AJ; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Terry-Kantor E; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Nuber S; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Ericsson M; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Fanning S; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Bartels T; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Lindquist S; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Levy OA; HHMI, Department of Biology, MIT, Cambridge, MA 02139, USA.
  • Selkoe D; Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
Hum Mol Genet ; 26(18): 3466-3481, 2017 09 15.
Article in En | MEDLINE | ID: mdl-28911198
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Full text: 1 Database: MEDLINE Main subject: Inclusion Bodies / Alpha-Synuclein / Mutation Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2017 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Inclusion Bodies / Alpha-Synuclein / Mutation Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2017 Type: Article Affiliation country: United States