IRAK4 kinase activity controls Toll-like receptor-induced inflammation through the transcription factor IRF5 in primary human monocytes.

Cushing, Leah; Winkler, Aaron; Jelinsky, Scott A; Lee, Katherine; Korver, Wouter; Hawtin, Rachael; Rao, Vikram R; Fleming, Margaret; Lin, Lih-Ling

Cushing, Leah; Winkler, Aaron; Jelinsky, Scott A; Lee, Katherine; Korver, Wouter; Hawtin, Rachael; Rao, Vikram R; Fleming, Margaret; Lin, Lih-Ling.

Affiliation

Cushing L; From the Departments of Inflammation and Immunology and.
Winkler A; From the Departments of Inflammation and Immunology and.
Jelinsky SA; From the Departments of Inflammation and Immunology and.
Lee K; Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts 02139 and.
Korver W; Nodality Inc., South San Francisco, California 94080.
Hawtin R; Nodality Inc., South San Francisco, California 94080.
Rao VR; From the Departments of Inflammation and Immunology and.
Fleming M; From the Departments of Inflammation and Immunology and.
Lin LL; From the Departments of Inflammation and Immunology and lih-ling.lin@pfizer.com.

J Biol Chem ; 292(45): 18689-18698, 2017 11 10.

Article in En | MEDLINE | ID: mdl-28924041

Subject(s)

I-kappa B Kinase/metabolism; Interferon Regulatory Factors/metabolism; Interleukin-1 Receptor-Associated Kinases/metabolism; Models, Immunological; Monocytes/metabolism; Toll-Like Receptor 7/agonists; Toll-Like Receptor 8/agonists; Active Transport, Cell Nucleus/drug effects; Animals; Cells, Cultured; Computational Biology; Cytokines/agonists; Cytokines/genetics; Cytokines/metabolism; Enzyme Activation/drug effects; Gene Expression Regulation/drug effects; Humans; I-kappa B Kinase/antagonists & inhibitors; I-kappa B Kinase/chemistry; Interferon Regulatory Factors/agonists; Interleukin-1 Receptor-Associated Kinases/antagonists & inhibitors; MAP Kinase Kinase Kinases/antagonists & inhibitors; MAP Kinase Kinase Kinases/chemistry; MAP Kinase Kinase Kinases/metabolism; Monocytes/cytology; Monocytes/drug effects; Monocytes/immunology; NF-kappa B/metabolism; NF-kappa B p50 Subunit/metabolism; Phosphorylation/drug effects; Protein Kinase Inhibitors/pharmacology; Protein Processing, Post-Translational/drug effects; Single-Cell Analysis; Toll-Like Receptor 7/metabolism; Toll-Like Receptor 8/metabolism

Key words

IKKß; IRAK4; IRF5; NFκB; TAK1; TLR; Toll-like receptor; cytokine; inflammation; interferon regulatory factor

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Full text: 1 Database: MEDLINE Main subject: Monocytes / Models, Immunological / I-kappa B Kinase / Interferon Regulatory Factors / Toll-Like Receptor 7 / Toll-Like Receptor 8 / Interleukin-1 Receptor-Associated Kinases Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2017 Type: Article

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