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A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential.
Wang, Jiaqi; Bardelli, Marco; Espinosa, Diego A; Pedotti, Mattia; Ng, Thiam-Seng; Bianchi, Siro; Simonelli, Luca; Lim, Elisa X Y; Foglierini, Mathilde; Zatta, Fabrizia; Jaconi, Stefano; Beltramello, Martina; Cameroni, Elisabetta; Fibriansah, Guntur; Shi, Jian; Barca, Taylor; Pagani, Isabel; Rubio, Alicia; Broccoli, Vania; Vicenzi, Elisa; Graham, Victoria; Pullan, Steven; Dowall, Stuart; Hewson, Roger; Jurt, Simon; Zerbe, Oliver; Stettler, Karin; Lanzavecchia, Antonio; Sallusto, Federica; Cavalli, Andrea; Harris, Eva; Lok, Shee-Mei; Varani, Luca; Corti, Davide.
Affiliation
  • Wang J; Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore.
  • Bardelli M; Insitute for Research in Biomedicine, Università della Svizzera italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.
  • Espinosa DA; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, 185 Li Ka Shing Center, 1951 Oxford Street, Berkeley, California, 94720-3370, USA.
  • Pedotti M; Insitute for Research in Biomedicine, Università della Svizzera italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.
  • Ng TS; Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore.
  • Bianchi S; Humabs BioMed SA a subsidiary of Vir Biotechnology, Inc., Via Mirasole 1, 6500 Bellinzona, Switzerland.
  • Simonelli L; Insitute for Research in Biomedicine, Università della Svizzera italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.
  • Lim EXY; Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore.
  • Foglierini M; Insitute for Research in Biomedicine, Università della Svizzera italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.
  • Zatta F; Humabs BioMed SA a subsidiary of Vir Biotechnology, Inc., Via Mirasole 1, 6500 Bellinzona, Switzerland.
  • Jaconi S; Humabs BioMed SA a subsidiary of Vir Biotechnology, Inc., Via Mirasole 1, 6500 Bellinzona, Switzerland.
  • Beltramello M; Humabs BioMed SA a subsidiary of Vir Biotechnology, Inc., Via Mirasole 1, 6500 Bellinzona, Switzerland.
  • Cameroni E; Humabs BioMed SA a subsidiary of Vir Biotechnology, Inc., Via Mirasole 1, 6500 Bellinzona, Switzerland.
  • Fibriansah G; Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore.
  • Shi J; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore; CryoEM unit, Department of Biological Sciences, National University of Singapore, Singapore 117557.
  • Barca T; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, 185 Li Ka Shing Center, 1951 Oxford Street, Berkeley, California, 94720-3370, USA.
  • Pagani I; Viral Pathogens and Biosafety Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.
  • Rubio A; Viral Pathogens and Biosafety Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.
  • Broccoli V; Viral Pathogens and Biosafety Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy; CNR-Institute of Neuroscience, Via Vanvitelli 32, 20129, Milan, Italy.
  • Vicenzi E; Viral Pathogens and Biosafety Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.
  • Graham V; National Infection Service, Public Health England, Porton Down, Salisbury, Wiltshire, UK.
  • Pullan S; National Infection Service, Public Health England, Porton Down, Salisbury, Wiltshire, UK.
  • Dowall S; National Infection Service, Public Health England, Porton Down, Salisbury, Wiltshire, UK.
  • Hewson R; National Infection Service, Public Health England, Porton Down, Salisbury, Wiltshire, UK.
  • Jurt S; Department of Chemistry, University of Zurich, Zurich, Switzerland.
  • Zerbe O; Department of Chemistry, University of Zurich, Zurich, Switzerland.
  • Stettler K; Humabs BioMed SA a subsidiary of Vir Biotechnology, Inc., Via Mirasole 1, 6500 Bellinzona, Switzerland.
  • Lanzavecchia A; Insitute for Research in Biomedicine, Università della Svizzera italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.
  • Sallusto F; Insitute for Research in Biomedicine, Università della Svizzera italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.
  • Cavalli A; Insitute for Research in Biomedicine, Università della Svizzera italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.
  • Harris E; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, 185 Li Ka Shing Center, 1951 Oxford Street, Berkeley, California, 94720-3370, USA.
  • Lok SM; Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore. Electronic address: sheemei.lok@duke-nus.edu.sg.
  • Varani L; Insitute for Research in Biomedicine, Università della Svizzera italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland. Electronic address: luca.varani@irb.usi.ch.
  • Corti D; Humabs BioMed SA a subsidiary of Vir Biotechnology, Inc., Via Mirasole 1, 6500 Bellinzona, Switzerland. Electronic address: davide.corti@humabs.ch.
Cell ; 171(1): 229-241.e15, 2017 Sep 21.
Article in En | MEDLINE | ID: mdl-28938115
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Full text: 1 Database: MEDLINE Main subject: Antibodies, Neutralizing / Zika Virus / Zika Virus Infection / Antibodies, Monoclonal / Antibodies, Viral Limits: Animals / Humans Language: En Journal: Cell Year: 2017 Type: Article Affiliation country: Singapore
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Antibodies, Neutralizing / Zika Virus / Zika Virus Infection / Antibodies, Monoclonal / Antibodies, Viral Limits: Animals / Humans Language: En Journal: Cell Year: 2017 Type: Article Affiliation country: Singapore