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Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics.
Piche-Nicholas, Nicole M; Avery, Lindsay B; King, Amy C; Kavosi, Mania; Wang, Mengmeng; O'Hara, Denise M; Tchistiakova, Lioudmila; Katragadda, Madan.
Affiliation
  • Piche-Nicholas NM; a BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.
  • Avery LB; b BioMedicine Design, Pfizer Inc. , Andover , MA , USA.
  • King AC; a BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.
  • Kavosi M; b BioMedicine Design, Pfizer Inc. , Andover , MA , USA.
  • Wang M; b BioMedicine Design, Pfizer Inc. , Andover , MA , USA.
  • O'Hara DM; b BioMedicine Design, Pfizer Inc. , Andover , MA , USA.
  • Tchistiakova L; a BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.
  • Katragadda M; a BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.
MAbs ; 10(1): 81-94, 2018 01.
Article in En | MEDLINE | ID: mdl-28991504
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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin G / Receptors, Fc / Histocompatibility Antigens Class I / Complementarity Determining Regions / Antibodies, Monoclonal Limits: Animals / Humans / Male Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin G / Receptors, Fc / Histocompatibility Antigens Class I / Complementarity Determining Regions / Antibodies, Monoclonal Limits: Animals / Humans / Male Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Type: Article Affiliation country: United States