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Emergence of ArmA, a 16S rRNA methylase in highly aminoglycoside-resistant clinical isolates of Klebsiella pneumoniae and Klebsiella oxytoca in Okinawa, Japan.
Uechi, Kohei; Tada, Tatsuya; Shimada, Kayo; Nakasone, Isamu; Sonozaki, Tetsu; Kirikae, Teruo; Fujita, Jiro.
Affiliation
  • Uechi K; Division of Clinical Laboratory and Blood Transfusion, University Hospital of the Ryukyus, Okinawa, Japan; Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Tada T; Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan; Department of Infectious Disease, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
  • Shimada K; Department of Infectious Disease, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
  • Nakasone I; Control and Prevention of Infectious Disease, University Hospital of the Ryukyus, Okinawa, Japan.
  • Sonozaki T; Department of Dermatology, University Hospital of the Ryukyus, Okinawa, Japan.
  • Kirikae T; Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan; Department of Infectious Disease, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. Electronic address: t-kirikae@juntendo.ac.jp.
  • Fujita J; Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
J Infect Chemother ; 24(1): 68-70, 2018 Jan.
Article in En | MEDLINE | ID: mdl-29066218
This study describes highly aminoglycoside-resistant Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates obtained from an inpatient in Okinawa, Japan, with no known record of traveling overseas. The minimum inhibitory concentrations of amikacin and arbekacin against these strains were >1024 µg/ml. Whole-genome sequencing analysis revealed that these isolates harbored armA, which encodes a 16S rRNA methylase, ArmA, that confers pan-aminoglycoside resistance. This is the second report of K. pneumoniae harboring armA and the first report of K. oxytoca harboring a 16S rRNA methylase encoding gene in Japan.
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Full text: 1 Database: MEDLINE Main subject: Klebsiella Infections / Drug Resistance, Bacterial / Klebsiella oxytoca / Aminoglycosides / Klebsiella pneumoniae / Methyltransferases Limits: Aged / Female / Humans Country/Region as subject: Asia Language: En Journal: J Infect Chemother Journal subject: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2018 Type: Article Affiliation country: Japan
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Full text: 1 Database: MEDLINE Main subject: Klebsiella Infections / Drug Resistance, Bacterial / Klebsiella oxytoca / Aminoglycosides / Klebsiella pneumoniae / Methyltransferases Limits: Aged / Female / Humans Country/Region as subject: Asia Language: En Journal: J Infect Chemother Journal subject: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2018 Type: Article Affiliation country: Japan