Practical management of behavioral problems in mucopolysaccharidoses disorders.
Mol Genet Metab
; 122S: 35-40, 2017 12.
Article
in En
| MEDLINE
| ID: mdl-29170079
ABSTRACT
The mucopolysaccharidosis (MPS) disorders are caused by deficiencies of specific lysosomal enzymes, resulting in progressive glycosaminoglycan (GAG) accumulation in cells and tissues throughout the body. Excessive GAG storage can lead to a variety of somatic manifestations as well as primary and secondary neurological symptoms. Behavioral problems (like hyperactivity, attention difficulties, and severe frustration) and sleeping problems are typical primary neurological symptoms of MPS caused by GAG accumulation in neurons, and are frequently observed in patients with MPS I, II, III, and VII. As these problems often place a significant burden on the family, proper management is important. This review summarizes current insights into behavioral and sleeping problems in MPS disorders and the most optimal management approaches, as presented and discussed during a meeting of an international group of experts with extensive experience in managing and treating MPS.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Behavior Therapy
/
Central Nervous System Depressants
/
Child Behavior
/
Mucopolysaccharidoses
/
Dyssomnias
Type of study:
Etiology_studies
Limits:
Child
/
Child, preschool
/
Humans
Language:
En
Journal:
Mol Genet Metab
Journal subject:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
/
METABOLISMO
Year:
2017
Type:
Article