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Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.
Berenjeno, Inma M; Piñeiro, Roberto; Castillo, Sandra D; Pearce, Wayne; McGranahan, Nicholas; Dewhurst, Sally M; Meniel, Valerie; Birkbak, Nicolai J; Lau, Evelyn; Sansregret, Laurent; Morelli, Daniele; Kanu, Nnennaya; Srinivas, Shankar; Graupera, Mariona; Parker, Victoria E R; Montgomery, Karen G; Moniz, Larissa S; Scudamore, Cheryl L; Phillips, Wayne A; Semple, Robert K; Clarke, Alan; Swanton, Charles; Vanhaesebroeck, Bart.
Affiliation
  • Berenjeno IM; UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street London, London, WC1E 6DD, UK. i.berenjeno@ucl.ac.uk.
  • Piñeiro R; UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street London, London, WC1E 6DD, UK.
  • Castillo SD; Roche-Chus Joint Unit, Complexo Hospitalario Universitario de Santiago de Compostela, Travesía da Choupana S/N, 15706, Santiago de Compostela, Spain.
  • Pearce W; UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street London, London, WC1E 6DD, UK.
  • McGranahan N; UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street London, London, WC1E 6DD, UK.
  • Dewhurst SM; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UCL Cancer Institute and Hospitals, 72 Huntley Street, London, WC1E 6DD, UK.
  • Meniel V; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UCL Cancer Institute and Hospitals, 72 Huntley Street, London, WC1E 6DD, UK.
  • Birkbak NJ; European Cancer Stem Cell Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK.
  • Lau E; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UCL Cancer Institute and Hospitals, 72 Huntley Street, London, WC1E 6DD, UK.
  • Sansregret L; UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street London, London, WC1E 6DD, UK.
  • Morelli D; UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street London, London, WC1E 6DD, UK.
  • Kanu N; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UCL Cancer Institute and Hospitals, 72 Huntley Street, London, WC1E 6DD, UK.
  • Srinivas S; UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street London, London, WC1E 6DD, UK.
  • Graupera M; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UCL Cancer Institute and Hospitals, 72 Huntley Street, London, WC1E 6DD, UK.
  • Parker VER; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, OX1 2JD, UK.
  • Montgomery KG; Vascular Signalling Laboratory, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, 08908, Spain.
  • Moniz LS; Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
  • Scudamore CL; Cancer Biology and Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, 3000, VIC, Australia.
  • Phillips WA; UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street London, London, WC1E 6DD, UK.
  • Semple RK; Mary Lyon Centre, MRC Harwell, Harwell, OX11 0RD, UK.
  • Clarke A; Cancer Biology and Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, 3000, VIC, Australia.
  • Swanton C; Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
  • Vanhaesebroeck B; European Cancer Stem Cell Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK.
Nat Commun ; 8(1): 1773, 2017 11 24.
Article in En | MEDLINE | ID: mdl-29170395
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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Gene Amplification / Genome / Centrosome / Phosphatidylinositol 3-Kinases / Class I Phosphatidylinositol 3-Kinases Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Type: Article Affiliation country: United kingdom
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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Gene Amplification / Genome / Centrosome / Phosphatidylinositol 3-Kinases / Class I Phosphatidylinositol 3-Kinases Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Type: Article Affiliation country: United kingdom