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Discovery of novel purine nucleoside derivatives as phosphodiesterase 2 (PDE2) inhibitors: Structure-based virtual screening, optimization and biological evaluation.
Qiu, Xiaoxia; Huang, Yiyou; Wu, Deyan; Mao, Fei; Zhu, Jin; Yan, Wenzhong; Luo, Hai-Bin; Li, Jian.
Affiliation
  • Qiu X; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China.
  • Huang Y; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
  • Wu D; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
  • Mao F; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China.
  • Zhu J; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China.
  • Yan W; iHuman Institute, ShanghaiTech University, 99 Haike Road, Shanghai 201210, China. Electronic address: yanwzh@shanghaitech.edu.cn.
  • Luo HB; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China. Electronic address: luohb77@mail.sysu.edu.cn.
  • Li J; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China. Electronic address: jianli@ecust.edu.cn.
Bioorg Med Chem ; 26(1): 119-133, 2018 01 01.
Article in En | MEDLINE | ID: mdl-29174506
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Full text: 1 Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Purines / Cyclic Nucleotide Phosphodiesterases, Type 2 / Drug Discovery / Nucleosides Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Purines / Cyclic Nucleotide Phosphodiesterases, Type 2 / Drug Discovery / Nucleosides Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Type: Article Affiliation country: China