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Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation.
Uthman, Laween; Baartscheer, Antonius; Bleijlevens, Boris; Schumacher, Cees A; Fiolet, Jan W T; Koeman, Anneke; Jancev, Milena; Hollmann, Markus W; Weber, Nina C; Coronel, Ruben; Zuurbier, Coert J.
Affiliation
  • Uthman L; Laboratory of Experimental Intensive Care and Anaesthesiology, Department of Anaesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
  • Baartscheer A; Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Bleijlevens B; Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Schumacher CA; Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Fiolet JWT; Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Koeman A; Laboratory of Experimental Intensive Care and Anaesthesiology, Department of Anaesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
  • Jancev M; Laboratory of Experimental Intensive Care and Anaesthesiology, Department of Anaesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
  • Hollmann MW; Laboratory of Experimental Intensive Care and Anaesthesiology, Department of Anaesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
  • Weber NC; Laboratory of Experimental Intensive Care and Anaesthesiology, Department of Anaesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
  • Coronel R; Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Zuurbier CJ; Laboratory of Experimental Intensive Care and Anaesthesiology, Department of Anaesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. c.j.zuurbier@amc.uva.nl.
Diabetologia ; 61(3): 722-726, 2018 Mar.
Article in En | MEDLINE | ID: mdl-29197997
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Full text: 1 Database: MEDLINE Main subject: Sodium / Sodium-Hydrogen Exchangers / Cytosol / Myocytes, Cardiac / Sodium-Glucose Transporter 2 / Sodium-Glucose Transporter 2 Inhibitors Limits: Animals Language: En Journal: Diabetologia Year: 2018 Type: Article Affiliation country: Netherlands
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Full text: 1 Database: MEDLINE Main subject: Sodium / Sodium-Hydrogen Exchangers / Cytosol / Myocytes, Cardiac / Sodium-Glucose Transporter 2 / Sodium-Glucose Transporter 2 Inhibitors Limits: Animals Language: En Journal: Diabetologia Year: 2018 Type: Article Affiliation country: Netherlands