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New microtubulin inhibitor MT189 suppresses angiogenesis via the JNK-VEGF/VEGFR2 signaling axis.
Xu, Lin; Wang, Wei; Meng, Tao; Ma, Lan-Ping; Tong, Lin-Jiang; Shen, Jing-Kang; Wang, Ying-Qing; Miao, Ze-Hong.
Affiliation
  • Xu L; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, NO.19A Yuquan Road, Beijing 100049, China.
  • Wang W; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Meng T; Division of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Ma LP; Division of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Tong LJ; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Shen JK; Division of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Wang YQ; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: yqwang@simm.ac.cn.
  • Miao ZH; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: zhmiao@simm.ac.cn.
Cancer Lett ; 416: 57-65, 2018 03 01.
Article in En | MEDLINE | ID: mdl-29248713
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Full text: 1 Database: MEDLINE Main subject: Pyridines / Signal Transduction / Vascular Endothelial Growth Factor Receptor-2 / Vascular Endothelial Growth Factor A / JNK Mitogen-Activated Protein Kinases / Microvessels / Imidazoles Limits: Animals / Humans Language: En Journal: Cancer Lett Year: 2018 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Pyridines / Signal Transduction / Vascular Endothelial Growth Factor Receptor-2 / Vascular Endothelial Growth Factor A / JNK Mitogen-Activated Protein Kinases / Microvessels / Imidazoles Limits: Animals / Humans Language: En Journal: Cancer Lett Year: 2018 Type: Article Affiliation country: China