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The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particle types.
Denolly, Solène; Mialon, Chloé; Bourlet, Thomas; Amirache, Fouzia; Penin, François; Lindenbach, Brett; Boson, Bertrand; Cosset, François-Loïc.
Affiliation
  • Denolly S; CIRI-International Center for Infectiology Research, Team EVIR, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Univ Lyon, Lyon, France.
  • Mialon C; CIRI-International Center for Infectiology Research, Team EVIR, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Univ Lyon, Lyon, France.
  • Bourlet T; GIMAP, EA 3064, Faculté de Médecine, Université de Saint-Etienne, Univ Lyon, Saint Etienne, France.
  • Amirache F; CIRI-International Center for Infectiology Research, Team EVIR, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Univ Lyon, Lyon, France.
  • Penin F; IBCP-Institut de Biologie et Chimie des Protéines, MMSB, UMR 5086, CNRS, Univ Lyon, Lyon, France.
  • Lindenbach B; Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, United States of America.
  • Boson B; CIRI-International Center for Infectiology Research, Team EVIR, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Univ Lyon, Lyon, France.
  • Cosset FL; CIRI-International Center for Infectiology Research, Team EVIR, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Univ Lyon, Lyon, France.
PLoS Pathog ; 13(12): e1006774, 2017 12.
Article in En | MEDLINE | ID: mdl-29253880

Full text: 1 Database: MEDLINE Main subject: Viral Proteins / Viral Envelope Proteins / Hepacivirus Type of study: Etiology_studies Limits: Humans Language: En Journal: PLoS Pathog Year: 2017 Type: Article Affiliation country: France

Full text: 1 Database: MEDLINE Main subject: Viral Proteins / Viral Envelope Proteins / Hepacivirus Type of study: Etiology_studies Limits: Humans Language: En Journal: PLoS Pathog Year: 2017 Type: Article Affiliation country: France