Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549.

Bistrovic, Andrea; Grbcic, Petra; Harej, Anja; Sedic, Mirela; Kraljevic-Pavelic, Sandra; Kostrun, Sanja; Plavec, Janez; Makuc, Damjan; Raic-Malic, Silvana

Bistrovic, Andrea; Grbcic, Petra; Harej, Anja; Sedic, Mirela; Kraljevic-Pavelic, Sandra; Kostrun, Sanja; Plavec, Janez; Makuc, Damjan; Raic-Malic, Silvana.

Affiliation

Bistrovic A; a Department of Organic Chemistry, Faculty of Chemical Engineering and Technology , University of Zagreb , Zagreb , Croatia.
Grbcic P; b Department of Biotechnology, Center for High-Throughput Technologies , University of Rijeka , Rijeka , Croatia.
Harej A; b Department of Biotechnology, Center for High-Throughput Technologies , University of Rijeka , Rijeka , Croatia.
Sedic M; b Department of Biotechnology, Center for High-Throughput Technologies , University of Rijeka , Rijeka , Croatia.
Kraljevic-Pavelic S; b Department of Biotechnology, Center for High-Throughput Technologies , University of Rijeka , Rijeka , Croatia.
Kostrun S; c Chemistry Department , Fidelta Ltd. , Zagreb , Croatia.
Plavec J; d Slovenian NMR Centre , National Institute of Chemistry , Ljubljana , Slovenia.
Makuc D; e En-FIST Centre of Excellence , Ljubljana , Slovenia.
Raic-Malic S; f Faculty of Chemistry and Chemical Technology , University of Ljubljana , Ljubljana , Slovenia.

J Enzyme Inhib Med Chem ; 33(1): 271-285, 2018 Dec.

Article in En | MEDLINE | ID: mdl-29271659

Subject(s)

Antineoplastic Agents/pharmacology; Carcinoma, Non-Small-Cell Lung/drug therapy; Cytostatic Agents/pharmacology; Lung Neoplasms/drug therapy; Purines/pharmacology; Small Molecule Libraries/pharmacology; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Apoptosis/drug effects; Carcinoma, Non-Small-Cell Lung/pathology; Cell Proliferation/drug effects; Cells, Cultured; Cytostatic Agents/chemical synthesis; Cytostatic Agents/chemistry; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms/pathology; Models, Molecular; Molecular Structure; Purines/chemical synthesis; Purines/chemistry; Small Molecule Libraries/chemical synthesis; Small Molecule Libraries/chemistry; Structure-Activity Relationship; Triazoles/chemistry; Triazoles/pharmacology

Key words

1,2,3-triazole; Purine; non-small cell lung cancer A549; p38 MAPK; purinomimetic

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Full text: 1 Database: MEDLINE Main subject: Purines / Carcinoma, Non-Small-Cell Lung / Small Molecule Libraries / Cytostatic Agents / Lung Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Type: Article Affiliation country: Croatia

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