Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation.

Lv, Lin-Li; Feng, Ye; Wen, Yi; Wu, Wei-Jun; Ni, Hai-Feng; Li, Zuo-Lin; Zhou, Le-Ting; Wang, Bin; Zhang, Jian-Dong; Crowley, Steven D; Liu, Bi-Cheng

Lv, Lin-Li; Feng, Ye; Wen, Yi; Wu, Wei-Jun; Ni, Hai-Feng; Li, Zuo-Lin; Zhou, Le-Ting; Wang, Bin; Zhang, Jian-Dong; Crowley, Steven D; Liu, Bi-Cheng.

Affiliation

Lv LL; Institute of Nephrology, Zhongda Hospitial, Southeast University School of Medicine, Nanjing, China; and.
Feng Y; Institute of Nephrology, Zhongda Hospitial, Southeast University School of Medicine, Nanjing, China; and.
Wen Y; Institute of Nephrology, Zhongda Hospitial, Southeast University School of Medicine, Nanjing, China; and.
Wu WJ; Institute of Nephrology, Zhongda Hospitial, Southeast University School of Medicine, Nanjing, China; and.
Ni HF; Institute of Nephrology, Zhongda Hospitial, Southeast University School of Medicine, Nanjing, China; and.
Li ZL; Institute of Nephrology, Zhongda Hospitial, Southeast University School of Medicine, Nanjing, China; and.
Zhou LT; Institute of Nephrology, Zhongda Hospitial, Southeast University School of Medicine, Nanjing, China; and.
Wang B; Institute of Nephrology, Zhongda Hospitial, Southeast University School of Medicine, Nanjing, China; and.
Zhang JD; Institute of Nephrology, Zhongda Hospitial, Southeast University School of Medicine, Nanjing, China; and.
Crowley SD; Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina.
Liu BC; Institute of Nephrology, Zhongda Hospitial, Southeast University School of Medicine, Nanjing, China; and liubc64@163.com.

J Am Soc Nephrol ; 29(3): 919-935, 2018 03.

Article in En | MEDLINE | ID: mdl-29295871

Subject(s)

Acute Kidney Injury/metabolism; Chemokine CCL2/genetics; Chemokine CCL2/metabolism; Epithelial Cells/metabolism; Exosomes/metabolism; Glomerulonephritis, IGA/urine; Kidney Tubules/metabolism; Macrophages/metabolism; RNA, Messenger/metabolism; Renal Insufficiency, Chronic/metabolism; Acute Kidney Injury/genetics; Acute Kidney Injury/urine; Adult; Animals; Cell Movement/drug effects; Cells, Cultured; Disease Models, Animal; Exosomes/genetics; Female; Gene Silencing; Glomerulonephritis, IGA/complications; Glomerulonephritis, IGA/pathology; Humans; Kidney Tubules/cytology; Kidney Tubules/pathology; Macrophages/physiology; Male; Mice; Middle Aged; Nephritis/metabolism; Nephritis/pathology; Proteinuria/etiology; Proteinuria/pathology; Proteinuria/urine; Rats; Renal Insufficiency, Chronic/genetics; Renal Insufficiency, Chronic/urine; Serum Albumin, Bovine/pharmacology; Young Adult

Key words

CCL2; albuminuria; exosome; extracellular vesicle; mRNA; macrophages

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Full text: 1 Database: MEDLINE Main subject: RNA, Messenger / Chemokine CCL2 / Epithelial Cells / Renal Insufficiency, Chronic / Exosomes / Acute Kidney Injury / Glomerulonephritis, IGA / Kidney Tubules / Macrophages Type of study: Etiology_studies / Prognostic_studies Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Am Soc Nephrol Journal subject: NEFROLOGIA Year: 2018 Type: Article

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