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Detection of carbapenemase activity in Pseudomonas aeruginosa by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS).
Miltgen, G; Plésiat, P; Mille, A; Chatelain, P; Fournier, D.
Affiliation
  • Miltgen G; Laboratoire de Bactériologie, CHU Félix Guyon, Saint-Denis, La Réunion, France; UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), CNRS 9192, INSERM U1187, IRD 249, Université de La Réunion, Sainte-Clotilde, La Réunion, France.
  • Plésiat P; Centre National de Référence de la Résistance aux Antibiotiques, Centre Hospitalier Régional Universitaire de Besançon, France; Laboratoire de Bactériologie, UMR CNRS 6249 Chrono-Environnement, Université Bourgogne Franche-Comté, Besançon, France.
  • Mille A; Centre National de Référence de la Résistance aux Antibiotiques, Centre Hospitalier Régional Universitaire de Besançon, France.
  • Chatelain P; Centre National de Référence de la Résistance aux Antibiotiques, Centre Hospitalier Régional Universitaire de Besançon, France.
  • Fournier D; Centre National de Référence de la Résistance aux Antibiotiques, Centre Hospitalier Régional Universitaire de Besançon, France; Laboratoire de Bactériologie, UMR CNRS 6249 Chrono-Environnement, Université Bourgogne Franche-Comté, Besançon, France. Electronic address: dfournier@chu-besancon.fr.
J Microbiol Methods ; 145: 66-68, 2018 02.
Article in En | MEDLINE | ID: mdl-29307737
A new MALDI-TOF MS imipenem hydrolysis assay was developed to optimize detection of carbapenemase-producing strains of Pseudomonas aeruginosa. The method correctly discriminated carbapenemase producers (n=74) from non-producers (n=95) in 99.4% of cases, and successfully detected 100% GES-5 strains (n=5).
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Full text: 1 Database: MEDLINE Main subject: Pseudomonas aeruginosa / Pseudomonas Infections / Bacterial Proteins / Beta-Lactamases / Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Microbiol Methods Year: 2018 Type: Article Affiliation country: France
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Full text: 1 Database: MEDLINE Main subject: Pseudomonas aeruginosa / Pseudomonas Infections / Bacterial Proteins / Beta-Lactamases / Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Microbiol Methods Year: 2018 Type: Article Affiliation country: France