Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery.
Br J Surg
; 105(2): e131-e141, 2018 01.
Article
in En
| MEDLINE
| ID: mdl-29341151
ABSTRACT
BACKGROUND:
The pathogenesis of colorectal cancer recurrence after a curative resection remains poorly understood. A yet-to-be accounted for variable is the composition and function of the microbiome adjacent to the tumour and its influence on the margins of resection following surgery.METHODS:
PubMed was searched for historical as well as current manuscripts dated between 1970 and 2017 using the following keywords 'colorectal cancer recurrence', 'microbiome', 'anastomotic leak', 'anastomotic failure' and 'mechanical bowel preparation'.RESULTS:
There is a substantial and growing body of literature to demonstrate the various mechanisms by which environmental factors act on the microbiome to alter its composition and function with the net result of adversely affecting oncological outcomes following surgery. Some of these environmental factors include diet, antibiotic use, the methods used to prepare the colon for surgery and the physiological stress of the operation itself.CONCLUSION:
Interrogating the intestinal microbiome using next-generation sequencing technology has the potential to influence cancer outcomes following colonic resection.
Full text:
1
Database:
MEDLINE
Main subject:
Colorectal Neoplasms
/
Anastomotic Leak
/
Gastrointestinal Microbiome
/
Neoplasm Recurrence, Local
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
Br J Surg
Year:
2018
Type:
Article
Affiliation country:
United States