MicroRNAs and Target Genes in Pituitary Adenomas.
Horm Metab Res
; 50(3): 179-192, 2018 03.
Article
in En
| MEDLINE
| ID: mdl-29351706
ABSTRACT
Pituitary adenomas account for the top three primary intracranial tumors in terms of total incidence rates. The clinical symptoms presented by the disease are often characterized by a series of systemic endocrine disorders, severe occupational lesions, and even some malignant features, and therefore early diagnosis and predicting recurrence would be instructive for clinical treatment of pituitary adenomas. An increasing number of specific microRNA (miRNA) expression signatures have been identified in pituitary, and miRNAs are related with the pituitary tumorigenesis, dysfunction, neurodegeneration, and metastatic non-functioning pituitary carcinoma. Here, this paper reviews the effects of aberrant miRNA expression in human pituitary adenomas and summarizes some corresponding target genes and biological significance over the last 7 years (2010-2017).
Full text:
1
Database:
MEDLINE
Main subject:
Pituitary Neoplasms
/
Adenoma
/
Gene Expression Regulation, Neoplastic
/
MicroRNAs
Type of study:
Screening_studies
Limits:
Humans
Language:
En
Journal:
Horm Metab Res
Year:
2018
Type:
Article
Affiliation country:
China