Dynamic cycling of t-SNARE acylation regulates platelet exocytosis.

Zhang, Jinchao; Huang, Yunjie; Chen, Jing; Zhu, Haining; Whiteheart, Sidney W

Zhang, Jinchao; Huang, Yunjie; Chen, Jing; Zhu, Haining; Whiteheart, Sidney W.

Affiliation

Zhang J; From the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536.
Huang Y; From the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536.
Chen J; From the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536.
Zhu H; From the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536.
Whiteheart SW; From the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536 whitehe@uky.edu.

J Biol Chem ; 293(10): 3593-3606, 2018 03 09.

Article in En | MEDLINE | ID: mdl-29352103

Subject(s)

Blood Platelets/metabolism; Cysteine/metabolism; Exocytosis; Protein Processing, Post-Translational; Qa-SNARE Proteins/metabolism; Qb-SNARE Proteins/metabolism; Qc-SNARE Proteins/metabolism; Acylation/drug effects; Acyltransferases/antagonists & inhibitors; Acyltransferases/metabolism; Blood Platelets/drug effects; Blood Platelets/enzymology; Cysteine/chemistry; Enzyme Inhibitors/pharmacology; Exocytosis/drug effects; Humans; Hydroxylamine/pharmacology; Membrane Microdomains/drug effects; Membrane Microdomains/metabolism; Oxidation-Reduction; P-Selectin/metabolism; Palmitic Acid/metabolism; Platelet Activation/drug effects; Platelet Aggregation/drug effects; Protein Processing, Post-Translational/drug effects; Protein Transport/drug effects; Qa-SNARE Proteins/chemistry; Qb-SNARE Proteins/chemistry; Qc-SNARE Proteins/chemistry; Reducing Agents/pharmacology; Surface Properties/drug effects; Thiolester Hydrolases/antagonists & inhibitors; Thiolester Hydrolases/metabolism; Tritium

Key words

SNAP-23; acyltransferase; cardiovascular; cerulenin; lipid raft; membrane fusion; palmostatin B; posttranslational modification (PTM); syntaxin; thrombosis

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Full text: 1 Database: MEDLINE Main subject: Blood Platelets / Protein Processing, Post-Translational / Cysteine / Qa-SNARE Proteins / Qb-SNARE Proteins / Qc-SNARE Proteins / Exocytosis Limits: Humans Language: En Journal: J Biol Chem Year: 2018 Type: Article

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