Utility of prenatal Doppler ultrasound to predict neonatal impaired cerebral autoregulation.
J Perinatol
; 38(5): 474-481, 2018 05.
Article
in En
| MEDLINE
| ID: mdl-29410542
ABSTRACT
OBJECTIVE:
Determine if abnormal prenatal Doppler ultrasound indices are predictive of postnatal impaired cerebral autoregulation. STUDYDESIGN:
Prospective cohort study of 46 subjects, 240-296 weeks' gestation. Utilizing near-infrared spectroscopy and receiver-operating characteristic analysis, impaired cerebral autoregulation was defined as >16.5% time spent in a dysregulated state within 96 h of life. Normal and abnormal Doppler indices were compared for perinatal outcomes.RESULTS:
Subjects with abnormal cerebroplacental ratio (n = 12) and abnormal umbilical artery pulsatility index (n = 13) were likely to develop postnatal impaired cerebral autoregulation (p ≤ 0.02). Abnormal cerebroplacental ratio was associated with impaired cerebral autoregulation between 24 and 48 h of life (p = 0.016). These subjects have increased risk for fetal growth restriction, lower birth weight, lower Apgar scores, acidosis, and severe intraventricular hemorrhage and/or death (p < 0.05).CONCLUSION:
Abnormal cerebroplacental ratio and umbilical artery pulsatility index are associated with postnatal impairment in cerebral autoregulation and adverse outcome.
Full text:
1
Database:
MEDLINE
Main subject:
Umbilical Arteries
/
Pulsatile Flow
/
Middle Cerebral Artery
/
Cerebrum
/
Fetal Diseases
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
J Perinatol
Journal subject:
PERINATOLOGIA
Year:
2018
Type:
Article
Affiliation country:
United States