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Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis.
Zhao, Dongxin; Badur, Mehmet G; Luebeck, Jens; Magaña, Jose H; Birmingham, Amanda; Sasik, Roman; Ahn, Christopher S; Ideker, Trey; Metallo, Christian M; Mali, Prashant.
Affiliation
  • Zhao D; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
  • Badur MG; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
  • Luebeck J; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, CA, USA.
  • Magaña JH; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
  • Birmingham A; Center for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA, USA.
  • Sasik R; Center for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA, USA.
  • Ahn CS; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
  • Ideker T; Department of Medicine, Division of Genetics, University of California, San Diego, La Jolla, CA, USA; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
  • Metallo CM; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. Electronic address: cmetallo@ucsd.edu.
  • Mali P; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. Electronic address: pmali@ucsd.edu.
Mol Cell ; 69(4): 699-708.e7, 2018 02 15.
Article in En | MEDLINE | ID: mdl-29452643
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Full text: 1 Database: MEDLINE Main subject: NF-E2-Related Factor 2 / Metabolic Networks and Pathways / Transcriptome / CRISPR-Cas Systems / Kelch-Like ECH-Associated Protein 1 Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2018 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Database: MEDLINE Main subject: NF-E2-Related Factor 2 / Metabolic Networks and Pathways / Transcriptome / CRISPR-Cas Systems / Kelch-Like ECH-Associated Protein 1 Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2018 Type: Article Affiliation country: United States