Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson's Disease Models.

Iannielli, Angelo; Bido, Simone; Folladori, Lucrezia; Segnali, Alice; Cancellieri, Cinzia; Maresca, Alessandra; Massimino, Luca; Rubio, Alicia; Morabito, Giuseppe; Caporali, Leonardo; Tagliavini, Francesca; Musumeci, Olimpia; Gregato, Giuliana; Bezard, Erwan; Carelli, Valerio; Tiranti, Valeria; Broccoli, Vania

Iannielli, Angelo; Bido, Simone; Folladori, Lucrezia; Segnali, Alice; Cancellieri, Cinzia; Maresca, Alessandra; Massimino, Luca; Rubio, Alicia; Morabito, Giuseppe; Caporali, Leonardo; Tagliavini, Francesca; Musumeci, Olimpia; Gregato, Giuliana; Bezard, Erwan; Carelli, Valerio; Tiranti, Valeria; Broccoli, Vania.

Affiliation

Iannielli A; Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.
Bido S; Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.
Folladori L; Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.
Segnali A; Molecular Neurogenetics Unit, IRCCS Foundation C. Besta Neurological Institute, 20126 Milan, Italy.
Cancellieri C; Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.
Maresca A; IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy.
Massimino L; University of Milano-Bicocca, Department of Medicine and Surgery, Monza, Italy.
Rubio A; Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; National Research Council (CNR), Institute of Neuroscience, 20129 Milan, Italy.
Morabito G; Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; University of Milano-Bicocca, Milan, Italy.
Caporali L; IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy.
Tagliavini F; IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy.
Musumeci O; Department of Neuroscience, University of Messina, Messina, Italy.
Gregato G; Division of Clinical Haematology-Oncology, European Institute of Oncology, Milan, Italy.
Bezard E; Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.
Carelli V; IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy; Neurology Unit, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Tiranti V; Molecular Neurogenetics Unit, IRCCS Foundation C. Besta Neurological Institute, 20126 Milan, Italy.
Broccoli V; Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; National Research Council (CNR), Institute of Neuroscience, 20129 Milan, Italy. Electronic address: broccoli.vania@hsr.it.

Cell Rep ; 22(8): 2066-2079, 2018 02 20.

Article in En | MEDLINE | ID: mdl-29466734

Subject(s)

Apoptosis/drug effects; Dopaminergic Neurons/pathology; Neuroprotective Agents/pharmacology; Parkinson Disease/pathology; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Differentiation/drug effects; Disease Models, Animal; Dopaminergic Neurons/drug effects; GTP Phosphohydrolases/genetics; Induced Pluripotent Stem Cells/drug effects; Induced Pluripotent Stem Cells/metabolism; Lysosomes/drug effects; Lysosomes/metabolism; Male; Membrane Potential, Mitochondrial/drug effects; Mice, Inbred C57BL; Mitochondria/drug effects; Mitochondria/metabolism; Mutation/genetics; Necrosis; Neural Stem Cells/drug effects; Neural Stem Cells/metabolism; Oxidative Stress/drug effects; Small Molecule Libraries/pharmacology

Key words

OPA1; Parkinson's disease; apoptosis; cell death; iPSCs; mitochondria; necroptosis; necrosis; neurodegeneration

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Full text: 1 Database: MEDLINE Main subject: Parkinson Disease / Apoptosis / Neuroprotective Agents / Dopaminergic Neurons Limits: Animals Language: En Journal: Cell Rep Year: 2018 Type: Article Affiliation country: Italy

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