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T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells.
Beura, Lalit K; Wijeyesinghe, Sathi; Thompson, Emily A; Macchietto, Marissa G; Rosato, Pamela C; Pierson, Mark J; Schenkel, Jason M; Mitchell, Jason S; Vezys, Vaiva; Fife, Brian T; Shen, Steven; Masopust, David.
Affiliation
  • Beura LK; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Wijeyesinghe S; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Thompson EA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Macchietto MG; Institute for Health Informatics, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Rosato PC; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Pierson MJ; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Schenkel JM; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Mitchell JS; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Vezys V; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Fife BT; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
  • Shen S; Institute for Health Informatics, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Masopust D; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: masopust@umn.edu.
Immunity ; 48(2): 327-338.e5, 2018 02 20.
Article in En | MEDLINE | ID: mdl-29466758
ABSTRACT
Immunosurveillance of secondary lymphoid organs (SLO) is performed by central memory T cells that recirculate through blood. Resident memory T (Trm) cells remain parked in nonlymphoid tissues and often stably express CD69. We recently identified Trm cells within SLO, but the origin and phenotype of these cells remains unclear. Using parabiosis of "dirty" mice, we found that CD69 expression is insufficient to infer stable residence of SLO Trm cells. Restimulation of nonlymphoid memory CD8+ T cells within the skin or mucosa resulted in a substantial increase in bona fide Trm cells specifically within draining lymph nodes. SLO Trm cells derived from emigrants from nonlymphoid tissues and shared some transcriptional and phenotypic signatures associated with nonlymphoid Trm cells. These data indicate that nonlymphoid cells can give rise to SLO Trm cells and suggest vaccination strategies by which memory CD8+ T cell immunosurveillance can be regionalized to specific lymph nodes.
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Full text: 1 Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Immunologic Memory / Lymph Nodes Limits: Animals Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Immunologic Memory / Lymph Nodes Limits: Animals Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Type: Article Affiliation country: United States