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Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity.
Bueno, Oskía; Tobajas, Gloria; Quesada, Ernesto; Estévez-Gallego, Juan; Noppen, Sam; Camarasa, María-José; Díaz, José-Fernando; Liekens, Sandra; Priego, Eva-María; Pérez-Pérez, María-Jesús.
Affiliation
  • Bueno O; Instituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain.
  • Tobajas G; Instituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain.
  • Quesada E; Instituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain.
  • Estévez-Gallego J; Centro de Investigaciones Biológicas (CIB, CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
  • Noppen S; Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium.
  • Camarasa MJ; Instituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain.
  • Díaz JF; Centro de Investigaciones Biológicas (CIB, CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
  • Liekens S; Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium.
  • Priego EM; Instituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain. Electronic address: empriego@iqm.csic.es.
  • Pérez-Pérez MJ; Instituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain. Electronic address: mjperez@iqm.csic.es.
Eur J Med Chem ; 148: 337-348, 2018 Mar 25.
Article in En | MEDLINE | ID: mdl-29471122
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Full text: 1 Database: MEDLINE Main subject: Tubulin / Chalcones / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2018 Type: Article Affiliation country: Spain
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Full text: 1 Database: MEDLINE Main subject: Tubulin / Chalcones / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2018 Type: Article Affiliation country: Spain