Fasudil and DETA NONOate, Loaded in a Peptide-Modified Liposomal Carrier, Slow PAH Progression upon Pulmonary Delivery.

Rashid, Jahidur; Nahar, Kamrun; Raut, Snehal; Keshavarz, Ali; Ahsan, Fakhrul

Rashid, Jahidur; Nahar, Kamrun; Raut, Snehal; Keshavarz, Ali; Ahsan, Fakhrul.

Affiliation

Rashid J; Department of Pharmaceutical Sciences, School of Pharmacy , Texas Tech University Health Sciences Center , 1300 Coulter Drive , Amarillo , Texas 79106 , United States.
Nahar K; Department of Pharmaceutical Sciences, School of Pharmacy , Texas Tech University Health Sciences Center , 1300 Coulter Drive , Amarillo , Texas 79106 , United States.
Raut S; Department of Pharmaceutical Sciences, School of Pharmacy , Texas Tech University Health Sciences Center , 1300 Coulter Drive , Amarillo , Texas 79106 , United States.
Keshavarz A; Department of Pharmaceutical Sciences, School of Pharmacy , Texas Tech University Health Sciences Center , 1300 Coulter Drive , Amarillo , Texas 79106 , United States.
Ahsan F; Department of Pharmaceutical Sciences, School of Pharmacy , Texas Tech University Health Sciences Center , 1300 Coulter Drive , Amarillo , Texas 79106 , United States.

Mol Pharm ; 15(5): 1755-1765, 2018 05 07.

Article in En | MEDLINE | ID: mdl-29528655

Subject(s)

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives; Hypertension, Pulmonary/drug therapy; Liposomes/chemistry; Lung/drug effects; Nitric Oxide Donors/pharmacology; Peptides/pharmacology; Polyamines/pharmacology; Pulmonary Artery/drug effects; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology; Animals; Chemistry, Pharmaceutical/methods; Disease Progression; Hypertension, Pulmonary/metabolism; Lung/metabolism; Male; Monocrotaline/pharmacology; Myocytes, Smooth Muscle/drug effects; Myocytes, Smooth Muscle/metabolism; Pulmonary Artery/metabolism; Rats; Rats, Sprague-Dawley; Vasodilator Agents/pharmacology; rho-Associated Kinases/metabolism

Key words

CAR peptide; fasudil; inhalation delivery; nitric oxide donor; peptide-conjugated liposomes; pulmonary arterial hypertension

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Full text: 1 Database: MEDLINE Main subject: Peptides / Polyamines / Pulmonary Artery / 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / Nitric Oxide Donors / Hypertension, Pulmonary / Liposomes / Lung Limits: Animals Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2018 Type: Article Affiliation country: United States

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