Knockdown of MALAT1 enhances chemosensitivity of ovarian cancer cells to cisplatin through inhibiting the Notch1 signaling pathway.

Bai, Lin; Wang, Aihua; Zhang, Yali; Xu, Xiaofeng; Zhang, Xiao

Bai, Lin; Wang, Aihua; Zhang, Yali; Xu, Xiaofeng; Zhang, Xiao.

Affiliation

Bai L; Department of Obstetrics and Gynecology, The First People's Hospital of Shangqiu, No. 292 Kaixuan Nan Road, Suiyang District, Shangqiu 476100, China. Electronic address: bailin_sq@yeah.net.
Wang A; Department of Obstetrics and Gynecology, The First People's Hospital of Shangqiu, No. 292 Kaixuan Nan Road, Suiyang District, Shangqiu 476100, China.
Zhang Y; Department of Obstetrics and Gynecology, The First People's Hospital of Shangqiu, No. 292 Kaixuan Nan Road, Suiyang District, Shangqiu 476100, China.
Xu X; Department of Obstetrics and Gynecology, The First People's Hospital of Shangqiu, No. 292 Kaixuan Nan Road, Suiyang District, Shangqiu 476100, China.
Zhang X; Department of Obstetrics and Gynecology, The First People's Hospital of Shangqiu, No. 292 Kaixuan Nan Road, Suiyang District, Shangqiu 476100, China.

Exp Cell Res ; 366(2): 161-171, 2018 05 15.

Article in En | MEDLINE | ID: mdl-29548748

Subject(s)

Adenocarcinoma, Mucinous/drug therapy; Cisplatin/pharmacology; Cystadenocarcinoma, Serous/drug therapy; Drug Resistance, Neoplasm; Endometrial Neoplasms/drug therapy; Ovarian Neoplasms/drug therapy; RNA, Long Noncoding/genetics; Receptor, Notch1/metabolism; Adenocarcinoma, Mucinous/metabolism; Adenocarcinoma, Mucinous/secondary; Animals; Antineoplastic Agents/pharmacology; Apoptosis; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Cell Proliferation; Cystadenocarcinoma, Serous/metabolism; Cystadenocarcinoma, Serous/secondary; Endometrial Neoplasms/metabolism; Endometrial Neoplasms/secondary; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Ovarian Neoplasms/metabolism; Ovarian Neoplasms/pathology; Prognosis; Receptor, Notch1/genetics; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Key words

ABCC1; Chemosensitivity; Cisplatin; MALAT1; Notch1; Ovarian cancer

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Full text: 1 Database: MEDLINE Main subject: Ovarian Neoplasms / Cisplatin / Endometrial Neoplasms / Cystadenocarcinoma, Serous / Adenocarcinoma, Mucinous / Drug Resistance, Neoplasm / Receptor, Notch1 / RNA, Long Noncoding Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male / Middle aged Language: En Journal: Exp Cell Res Year: 2018 Type: Article

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