Near-Infrared Imaging with Indocyanine Green for Detection of Endometriosis Lesions (Gre-Endo Trial): A Pilot Study.
J Minim Invasive Gynecol
; 25(7): 1249-1254, 2018.
Article
in En
| MEDLINE
| ID: mdl-29551477
ABSTRACT
STUDY OBJECTIVE:
To evaluate near-infrared radiation imaging with intravenous indocyanine green (NIR-ICG) during laparoscopic intervention to identify endometriosis lesions.DESIGN:
A single-center, prospective, single-arm pilot study (Canadian Task Force classification II-2).SETTING:
An academic tertiary care and research center. PATIENTS Twenty-seven patients with symptomatic endometriosis were enrolled.INTERVENTIONS:
Patients underwent laparoscopic surgery using a laparoscopic system prototype with NIR-ICG. MEASUREMENTS AND MAINRESULTS:
A total of 116 suspected endometriosis lesions were removed from 27 patients. One hundred lesions had already been visualized in white light imaging by an expert surgeon; the remaining 16 were detected and removed using NIR-ICG. A total of 111 specimens were positive for endometriosis pathology. Positive predictive value of 95% and 97.8% and negative predictive value of 86.2% and 82.3% were found by white light imaging and NIR-ICG, respectively, with sensitivity of 85.6% and 82% and specificity of 95.2% and 97.9%, respectively.CONCLUSION:
NIR-ICG may be a tool for intraoperative diagnosis, confirmation of visible endometriosis lesions, and a marker for identifying occult endometriosis. Further prospective studies with a larger population sample are warranted to validate these encouraging preliminary results.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Spectroscopy, Near-Infrared
/
Coloring Agents
/
Endometriosis
/
Indocyanine Green
Type of study:
Diagnostic_studies
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
J Minim Invasive Gynecol
Journal subject:
GINECOLOGIA
Year:
2018
Type:
Article