Myeloid Differentiation Factor 88 and Interleukin-1R1 Signaling Contribute to Resistance to Coccidioides immitis.

Viriyakosol, Suganya; Walls, Lorraine; Okamoto, Sharon; Raz, Eyal; Williams, David L; Fierer, Joshua

Viriyakosol, Suganya; Walls, Lorraine; Okamoto, Sharon; Raz, Eyal; Williams, David L; Fierer, Joshua.

Affiliation

Viriyakosol S; Department of Medicine, UC San Diego School of Medicine, San Diego, California, USA.
Walls L; VA Healthcare, San Diego, California, USA.
Okamoto S; VA Healthcare, San Diego, California, USA.
Raz E; Department of Medicine, UC San Diego School of Medicine, San Diego, California, USA.
Williams DL; Department of Medicine, UC San Diego School of Medicine, San Diego, California, USA.
Fierer J; Department of Surgery, James H. Quillen College of Medicine and Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, Tennessee, USA.

Infect Immun ; 86(6)2018 06.

Article in En | MEDLINE | ID: mdl-29610256

Subject(s)

Coccidioides/immunology; Coccidioidomycosis/immunology; Myeloid Differentiation Factor 88/metabolism; Receptors, Interleukin-1 Type I/metabolism; Animals; Dendritic Cells; Lectins, C-Type/genetics; Lectins, C-Type/metabolism; Macrophages, Peritoneal/metabolism; Mice; Mice, Knockout; Myeloid Differentiation Factor 88/genetics; Receptors, Interleukin-1 Type I/genetics; Toll-Like Receptor 2/genetics; Toll-Like Receptor 2/metabolism; Toll-Like Receptor 4/genetics; Toll-Like Receptor 4/metabolism

Key words

Coccidioides; IL-18; IL-1R1; IL-1Ra; MyD88; TLR2; TLR4; innate immunity; ß-glucan

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Full text: 1 Database: MEDLINE Main subject: Coccidioides / Coccidioidomycosis / Myeloid Differentiation Factor 88 / Receptors, Interleukin-1 Type I Type of study: Prognostic_studies Limits: Animals Language: En Journal: Infect Immun Year: 2018 Type: Article Affiliation country: United States

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