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Triptorelin for Fertility Preservation in Adolescents Treated With Chemotherapy for Cancer.
Meli, Mariaclaudia; Caruso-Nicoletti, Manuela; La Spina, Milena; Nigro, Luca Lo; Samperi, Piera; D'Amico, Salvatore; Bellia, Francesco; Miraglia, Vito; Licciardello, Maria; Cannata, Emanuela; Marino, Silvia; Cimino, Carla; Puglisi, Federica; Valvo, Laura Lo; Pezzulla, Agnese; Russo, Giovanna; Di Cataldo, Andrea.
Affiliation
  • Meli M; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Caruso-Nicoletti M; Pediatric Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
  • La Spina M; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Nigro LL; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Samperi P; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • D'Amico S; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Bellia F; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Miraglia V; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Licciardello M; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Cannata E; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Marino S; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Cimino C; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Puglisi F; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Valvo LL; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Pezzulla A; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Russo G; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
  • Di Cataldo A; Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.
J Pediatr Hematol Oncol ; 40(4): 269-276, 2018 05.
Article in En | MEDLINE | ID: mdl-29620680
BACKGROUND: Triptorelin, a gonadotropin releasing hormone analogue, can be administered to postpubertal female individuals with cancer who receive chemotherapy to obtain menstrual suppression and decrease the risk of hemorrhage caused by thrombocytopenia. Our goal was to assess whether triptorelin also has a protective role against the gonadotoxicity of chemotherapy. PATIENTS AND METHODS: This retrospective observational study includes all postmenarchal female patients who presented to our Unit from 2000 to 2015 and received chemotherapy for cancer. They were administered depot triptorelin. We evaluated long-term ovarian function in order to detect clinical signs of ovarian damage, miscarriages, and pregnancies. Laboratory follow-up consisted in dosing serum follicle stimulating hormone, luteinizing hormone, prolactin, estradiol, and progesterone. Ultrasound of the ovaries was performed as well. RESULTS: Of 36 evaluable patients, 9 received hematopoietic stem cell transplantation (HSCT). The remaining 27 patients maintained normal ovarian function at clinical, laboratory, and ultrasound assessment. Five of them achieved spontaneous physiological pregnancy. Four of the 9 patients who underwent HSCT developed premature ovarian failure. CONCLUSION: Our study suggests that gonadotropin releasing hormone-a administered during chemotherapy can prevent premature ovarian failure in patients treated without HSCT and that it is not enough to preserve the ovarian function during HSCT. Hence, a prospective randomized trial with a larger population would be recommended.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Ovary / Primary Ovarian Insufficiency / Triptorelin Pamoate / Fertility Preservation / Neoplasms / Antineoplastic Agents Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Child / Female / Humans Language: En Journal: J Pediatr Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2018 Type: Article

Full text: 1 Database: MEDLINE Main subject: Ovary / Primary Ovarian Insufficiency / Triptorelin Pamoate / Fertility Preservation / Neoplasms / Antineoplastic Agents Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Child / Female / Humans Language: En Journal: J Pediatr Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2018 Type: Article