Cyclic ß-glucans at the bacteria-host cells interphase: One sugar ring to rule them all.
Cell Microbiol
; 20(6): e12850, 2018 06.
Article
in En
| MEDLINE
| ID: mdl-29624823
ABSTRACT
Cyclic ß-1,2-D-glucans (CßG) are natural bionanopolymers present in the periplasmic space of many Proteobacteria. These molecules are sugar rings made of 17 to 25 D-glucose units linked exclusively by ß-1,2-glycosidic bonds. CßG are important for environmental sensing and osmoadaptation in bacteria, but most importantly, they play key roles in complex host-cell interactions such as symbiosis, pathogenesis, and immunomodulation. In the last years, the identification and characterisation of the enzymes involved in the synthesis of CßG allowed to know in detail the steps necessary for the formation of these sugar rings. Due to its peculiar structure, CßG can complex large hydrophobic molecules, a feature possibly related to its function in the interaction with the host. The capabilities of the CßG to function as molecular boxes and to solubilise hydrophobic compounds are attractive for application in the development of drugs, in food industry, nanotechnology, and chemistry. More importantly, its excellent immunomodulatory properties led to the proposal of CßG as a new class of adjuvants for vaccine development.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Symbiosis
/
Proteobacteria
/
Beta-Glucans
/
Host-Pathogen Interactions
Language:
En
Journal:
Cell Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2018
Type:
Article
Affiliation country:
Argentina