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Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism.
Fiorillo, Marco; Peiris-Pagès, Maria; Sanchez-Alvarez, Rosa; Bartella, Lucia; Di Donna, Leonardo; Dolce, Vincenza; Sindona, Giovanni; Sotgia, Federica; Cappello, Anna Rita; Lisanti, Michael P.
Affiliation
  • Fiorillo M; Paterson Institute, University of Manchester, Withington M20 4BX, United Kingdom; Translational Medicine, School of Environment and Life Sciences, Biomedical Research Centre (BRC), University of Salford, Greater Manchester M5 4WT, United Kingdom; The Department of Pharmacy, Health and Nutritional Sc
  • Peiris-Pagès M; Paterson Institute, University of Manchester, Withington M20 4BX, United Kingdom.
  • Sanchez-Alvarez R; Paterson Institute, University of Manchester, Withington M20 4BX, United Kingdom.
  • Bartella L; The Department of Chemistry and Chemical Technologies (CTC) of the University of Calabria, Cosenza, Italy.
  • Di Donna L; The Department of Chemistry and Chemical Technologies (CTC) of the University of Calabria, Cosenza, Italy.
  • Dolce V; The Department of Pharmacy, Health and Nutritional Sciences, The University of Calabria, Cosenza, Italy.
  • Sindona G; The Department of Chemistry and Chemical Technologies (CTC) of the University of Calabria, Cosenza, Italy.
  • Sotgia F; Paterson Institute, University of Manchester, Withington M20 4BX, United Kingdom; Translational Medicine, School of Environment and Life Sciences, Biomedical Research Centre (BRC), University of Salford, Greater Manchester M5 4WT, United Kingdom. Electronic address: fsotgia@gmail.com.
  • Cappello AR; The Department of Pharmacy, Health and Nutritional Sciences, The University of Calabria, Cosenza, Italy. Electronic address: annarita.cappello@unical.it.
  • Lisanti MP; Paterson Institute, University of Manchester, Withington M20 4BX, United Kingdom; Translational Medicine, School of Environment and Life Sciences, Biomedical Research Centre (BRC), University of Salford, Greater Manchester M5 4WT, United Kingdom. Electronic address: M.P.Lisanti@salford.ac.uk.
Biochim Biophys Acta Bioenerg ; 1859(9): 984-996, 2018 09.
Article in En | MEDLINE | ID: mdl-29626418
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Full text: 1 Database: MEDLINE Main subject: Neoplastic Stem Cells / Biological Products / Plant Oils / Breast Neoplasms / Rho-Specific Guanine Nucleotide Dissociation Inhibitors / Hydroxymethylglutaryl CoA Reductases / Mevalonic Acid Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Biochim Biophys Acta Bioenerg Year: 2018 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Neoplastic Stem Cells / Biological Products / Plant Oils / Breast Neoplasms / Rho-Specific Guanine Nucleotide Dissociation Inhibitors / Hydroxymethylglutaryl CoA Reductases / Mevalonic Acid Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Biochim Biophys Acta Bioenerg Year: 2018 Type: Article