Structure-guided design and functional characterization of an artificial red light-regulated guanylate/adenylate cyclase for optogenetic applications.

Etzl, Stefan; Lindner, Robert; Nelson, Matthew D; Winkler, Andreas

Etzl, Stefan; Lindner, Robert; Nelson, Matthew D; Winkler, Andreas.

Affiliation

Etzl S; From the Institute of Biochemistry, Graz University of Technology, Petersgasse 12/II, 8010 Graz, Austria.
Lindner R; the Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg 69120, Germany, and.
Nelson MD; the Department of Biology, Saint Joseph's University, Philadelphia, Pennsylvania 19131.
Winkler A; From the Institute of Biochemistry, Graz University of Technology, Petersgasse 12/II, 8010 Graz, Austria, Andreas.Winkler@TUGraz.at.

J Biol Chem ; 293(23): 9078-9089, 2018 06 08.

Article in En | MEDLINE | ID: mdl-29695503

Subject(s)

Adenylyl Cyclases/genetics; Deinococcus/genetics; Guanylate Cyclase/genetics; Optogenetics/methods; Phytochrome/genetics; Synechocystis/enzymology; Adenylyl Cyclases/chemistry; Amino Acid Sequence; Animals; Caenorhabditis elegans; Crystallography, X-Ray; Deinococcus/chemistry; Guanylate Cyclase/chemistry; Light; Molecular Dynamics Simulation; Phytochrome/chemistry; Protein Conformation; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/genetics; Synechocystis/genetics

Key words

adenylate cyclase (adenylyl cyclase); adenylyl cyclase; allosteric regulation; bacteriophytochrome; guanylate cyclase (guanylyl cyclase); hydrogen-deuterium exchange; light regulation; optogenetics; photoreceptor; photosensor

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Full text: 1 Database: MEDLINE Main subject: Phytochrome / Adenylyl Cyclases / Deinococcus / Synechocystis / Optogenetics / Guanylate Cyclase Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2018 Type: Article Affiliation country: Austria

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