Trends in hospitalization rates for psoriasis flares since the introduction of biologics: a time series in France between 2005 and 2015.
J Eur Acad Dermatol Venereol
; 32(11): 1920-1929, 2018 Nov.
Article
in En
| MEDLINE
| ID: mdl-29729123
ABSTRACT
BACKGROUND:
In the late 2000s, the introduction of biologics transformed the prognosis for patients with moderate-to-severe psoriasis. We hypothesized that treatment with biologics may associate with a reduction in the hospitalization rate for psoriasis flares.OBJECTIVE:
To analyse changes over time in the hospitalization rate for psoriasis flares.METHODS:
We included inpatient stays in any of nine French hospitals between 2005 and 2015 for a psoriasis flare, as documented in the national inpatient database. In two centres, we also analysed data from the individual patients' electronic medical records.RESULTS:
A total of 3572 stays were included. The introduction of biologics was not associated with a decrease in the number of hospitalizations for a psoriasis flare; on the contrary, we observed a non-significant increase in the number of hospitalizations (13 hospitalizations for psoriasis flares per quarter per 10 000 beds). In the two-centre study, the introduction of biologics was associated with a significant increase in the hospitalization of patients receiving topical treatments only (520 hospitalizations per year per 10 000 beds) and those with a first psoriasis flare.CONCLUSION:
The number of hospitalizations for a psoriasis flare tended to increase between 2005 and 2015. The availability of additional treatment options might have increased patient demand and/or broadened the indications in clinical practice.
Full text:
1
Database:
MEDLINE
Main subject:
Psoriasis
/
Recurrence
/
Biological Products
/
Disease Progression
/
Hospitalization
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
J Eur Acad Dermatol Venereol
Journal subject:
DERMATOLOGIA
/
DOENCAS SEXUALMENTE TRANSMISSIVEIS
Year:
2018
Type:
Article
Affiliation country:
France