Balance of Go1&#945; and Go2&#945; expression regulates motor function via the striatal dopaminergic system.

Baron, Jens; Bilbao, Ainhoa; Hörtnagl, Heide; Birnbaumer, Lutz; Leixner, Sarah; Spanagel, Rainer; Ahnert-Hilger, Gudrun; Brunk, Irene

Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system.

Baron, Jens; Bilbao, Ainhoa; Hörtnagl, Heide; Birnbaumer, Lutz; Leixner, Sarah; Spanagel, Rainer; Ahnert-Hilger, Gudrun; Brunk, Irene.

Affiliation

Baron J; Institute of Integrative Neuroanatomy, Charité-Universitätsmedizin, Berlin, Germany.
Bilbao A; Medical Faculty, Behavioural Genetics Research Group, Institute of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Hörtnagl H; Department of Pharmacology, Innsbruck Medical University, Innsbruck, Austria.
Birnbaumer L; School of Medical Sciences, Catholic University of Argentina, Institute of Biomedical Research (BIOMED UCA-CONICET), Buenos Aires, Argentina.
Leixner S; Medical Faculty, Behavioural Genetics Research Group, Institute of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Spanagel R; Medical Faculty, Institute of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Ahnert-Hilger G; Institute of Integrative Neuroanatomy, Charité-Universitätsmedizin, Berlin, Germany.
Brunk I; Institute of Integrative Neuroanatomy, Charité-Universitätsmedizin, Berlin, Germany.

J Neurochem ; 146(4): 374-389, 2018 08.

Article in En | MEDLINE | ID: mdl-29747224

Subject(s)

Corpus Striatum/metabolism; Dopamine/metabolism; GTP-Binding Protein alpha Subunit, Gi2/metabolism; Motor Activity/genetics; Animals; Animals, Newborn; Biogenic Monoamines/metabolism; Cocaine/administration & dosage; Conditioning, Operant/physiology; Corpus Striatum/drug effects; Corpus Striatum/ultrastructure; Dopamine Uptake Inhibitors/administration & dosage; GTP-Binding Protein alpha Subunit, Gi2/genetics; GTP-Binding Protein alpha Subunits/metabolism; Gene Expression Regulation/drug effects; Gene Expression Regulation/genetics; Male; Mice; Mice, Transgenic; Monoamine Oxidase/metabolism; Motor Activity/physiology; Receptors, Dopamine D1/metabolism; Receptors, Dopamine D2/metabolism; Synapses/metabolism; Tyrosine 3-Monooxygenase/metabolism; Vesicular Monoamine Transport Proteins/metabolism

Key words

D1-D2 receptor signalling; Goα splice variants; behavioural sensitization; cocaine; conditioned place preference; motor function

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Full text: 1 Database: MEDLINE Main subject: Dopamine / Corpus Striatum / GTP-Binding Protein alpha Subunit, Gi2 / Motor Activity Limits: Animals Language: En Journal: J Neurochem Year: 2018 Type: Article Affiliation country: Germany

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